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Moderna, Merck see positive results from skin cancer vaccine

| By AFP |

The Moderna and Merck drug makers on Tuesday announced positive results from a trial in which messenger RNA technology was used for the first time to make personalized vaccines for skin cancer patients.

The mRNA technology proved vital in the development of vaccines against Covid-19, and scientists have long believed it could help fight other viruses and diseases like cancer.

In a preliminary trial, 150 people who had had their melanoma tumor surgically removed were given up to nine doses of the experimental vaccine alongside the skin cancer treatment Keytruda.

The study showed a 44 percent reduction in risk of death or relapse compared to patients who were only treated with Keytruda, an immunotherapy medicine.

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“Today’s results are highly encouraging for the field of cancer treatment,” Moderna’s Chief Executive Officer Stephane Bancel, said in a statement.

“mRNA has been transformative for COVID-19, and now, for the first time ever, we have demonstrated the potential for mRNA to have an impact on outcomes in a randomized clinical trial in melanoma.”

Moderna and Merck, known as MSD outside of North America, will soon publish the full results of the study, the results of which have not yet been peer-reviewed. The companies will also launch a Phase 3 trial in 2023, which involves a larger number of patients.

Messenger RNA is a molecule within cells that carries instructions to form proteins. Scientists can design them to make a particular protein in the body that can help fight viruses and other illnesses.

Moderna and drugmaker Pfizer-BioNTech were the first to use the technology to create the mRNA vaccines used to fight Covid-19.

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The melanoma vaccine is tailor-made to “prime the immune system so that a patient can generate a tailored antitumor response specific to their tumor mutation signature,” said Moderna’s statement.

Melanoma is the worst form of skin cancer, and nearly 325,000 new cases were diagnosed in 2020. Some 8,000 people are expected to die from melanoma in 2022, said the statement.

Moderna and Merck agreed in October to jointly develop the personalized skin cancer vaccine, for which they will share costs and profits.

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International

Mexico, Brazil and Colombia left out of Trump’s “Shield of the Americas” summit

Left-wing governments in Latin America, including Mexico, Brazil and Colombia, were excluded from the “Shield of the Americas” summit convened by U.S. President Donald Trump.

The meeting, held in Miami, Florida, brought together 12 presidents from across the continent to discuss strategies to combat drug cartels and organized crime.

In Mexico’s case, President Claudia Sheinbaum had recently rejected the use of military force as a solution to the drug trafficking problem. She has argued that her administration’s security strategy is producing results and emphasized that force alone is not the answer.

During the summit, Trump said that most narcotics entering the United States come through Mexico and referred to his previous conversations with Sheinbaum on the issue.

“I like the president very much, she’s a very good person,” Trump said. “But I told her: ‘Let me eradicate the cartels.’ And she said, ‘No, no, no, please, president.’ We have to eradicate them. We have to finish them.”

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The remarks highlighted ongoing differences between Washington and Mexico over how to confront drug trafficking networks operating across the region.

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International

Trump announces 17-nation alliance in the Americas to “destroy” drug cartels

U.S. President Donald Trump announced on Saturday the creation of a 17-nation alliance across the Americas aimed at dismantling drug cartels, during a regional summit held at his golf club in Doral.

Speaking to a group of allied leaders at the Shield of the Americas Summit, Trump said the initiative would rely on military force to eliminate powerful criminal networks operating throughout the hemisphere.

“The heart of our agreement is the commitment to use lethal military force to destroy these sinister cartels and terrorist networks. Once and for all, we will put an end to them,” Trump told the assembled heads of state.

The Republican leader argued that large portions of territory in the Western Hemisphere have fallen under the control of transnational gangs and pledged U.S. support to governments seeking to confront them. He even suggested the potential use of highly precise missiles against cartel leaders.

Before making the announcement, Trump greeted the roughly twelve leaders attending the summit, including close allies such as Javier Milei, Daniel Noboa and Nayib Bukele, whom he described as a “great president.”

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The meeting forms part of Trump’s broader regional strategy inspired by his reinterpretation of the Monroe Doctrine, which seeks to reinforce Washington’s influence in the Americas, strengthen security cooperation and counter the growing presence of powers such as China.

Trump pointed to recent U.S. actions in the region as examples of his administration’s approach, including the operation that led to the capture of former Venezuelan president Nicolás Maduro earlier this year.

The summit also takes place amid escalating international tensions following the conflict launched last week by the United States and Israel against Iran.

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International

Trump replaces Homeland Security Secretary Kristi Noem with Senator Markwayne Mullin

U.S. President Donald Trump announced Thursday the departure of Kristi Noem as Secretary of Homeland Security, one of the key architects of the administration’s policy of deporting undocumented immigrants.

Noem, who has been assigned a new role as a “special envoy” to Latin America, will be replaced starting March 31 by Republican Senator Markwayne Mullin, the president said in a message posted on his social media platform Truth Social.

According to media reports, Trump made the decision after Noem’s recent hearings in Congress, during which she faced tough questions regarding the awarding of a major public contract.

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