International

Moderna reduces production of COVID-19 vaccine

September 13 |

Drugmaker Moderna announced Wednesday that it is scaling back manufacturing of its COVID-19 vaccine, an updated version of which was approved this week by U.S. regulators.

Moderna said the decision is driven by lower post-pandemic demand that will help the company reach its target of 75% to 80% gross revenue growth sooner.

Moderna is in talks with its partners that fill vials and syringes with its messenger RNA-based COVID vaccines globally to reduce production, Stephen Hoge, president of the Massachusetts-based company, said in an interview.

The reduction, Hoge added, will help Moderna adapt to the endemic phase of the disease, which had led to a drop in demand for COVID vaccines as buyers have reduced orders for injections.

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Moderna predicted in August that U.S. demand for the vaccine would reach between 50 million and 100 million doses in the fall season. About 153.8 million COVID injections were administered in the U.S. in 2022, according to the Centers for Disease Control and Prevention.

“For the last two years, we’ve been in pandemic mode producing 1 billion doses a year,” Hoge said. “We’ve been waiting for the time when the pandemic is officially behind us and we need to restructure that manufacturing footprint.”

Following clearance from the U.S. Food and Drug Administration (FDA) on Monday, Moderna said it would begin shipping doses of the COVID vaccine throughout the United States.

The company has agreements to supply its vaccine to other countries, including Britain, Canada and Japan, but does not yet have an agreement with the European Union, according to Hoge, who also said COVID was the focus of Moderna’s manufacturing agreement with China.

Hoge added that while Moderna is urgently working to reduce COVID manufacturing, talks with third-party manufacturers, which will help produce the upcoming respiratory syncytial virus (RSV) and influenza vaccines that investors hope will begin to replace Moderna’s dwindling COVID revenues, could extend into next year.

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“These are relationships we will need for decades to come,” Hoge said.

Moderna also announced Wednesday that it had completed the regulatory filing for its RSV vaccine and that its flu vaccine had generated a stronger immune response against all four A and B strains of the virus compared with traditional flu vaccines in a late-stage trial.

The efficacy of Moderna’s flu vaccine was demonstrated in all age groups, including older patients, and proved to be safe and tolerable, according to the company.

Moderna also said it had found its vaccine to be equal or superior to Sanofi’s high-dose flu vaccine in a separate initial comparative study.

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International

Uribe requests freedom amid appeal of historic bribery conviction

Former Colombian President Álvaro Uribe on Monday requested that the Supreme Court restore his freedom while he appeals the historic 12-year house arrest sentence he received for bribery and procedural fraud.

Uribe, the most prominent figure of Colombia’s right wing, was convicted last week by a lower court for attempting to bribe paramilitary members into denying his ties to the violent anti-guerrilla squads.

Since Friday, the 73-year-old has been under house arrest at his residence in Rionegro, about 30 km from Medellín. The judge justified the measure by citing a risk of flight.

However, Uribe’s defense team rejected that argument and formally petitioned the court to immediately lift the detention order, claiming it lacks legal basis.

Uribe, a dominant force in Colombian politics for decades, is now the first former president in the country’s history to be convicted and placed under arrest, found guilty of witness tampering and obstruction of justice to prevent links to paramilitary groups.

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He has repeatedly denounced the trial as politically motivated, blaming pressure from the leftist government currently in power.

His political party, Centro Democrático, has called for nationwide protests on August 7 in support of Uribe, who remains popular for his hardline stance against guerrilla groups.

Uribe has until August 13 to submit his written appeal. The case will then move to the Bogotá High Court, which has until October 16 to uphold, overturn, or dismiss the sentence. If the deadline passes without a decision, the case will be archived.

International

U.S. Embassy staff restricted as gunfire erupts near compound in Port-au-Prince

The poorest country in Latin America and the Caribbean is currently engulfed in a deep political crisis and a wave of violence driven by armed groups — a situation that an international security mission led by Kenya is attempting to stabilize.

Due to the worsening security conditions, the U.S. government has suspended all official movements of embassy personnel outside the compound in Port-au-Prince, the U.S. State Department announced Monday in a security alert posted on social media platform X.

“There are intense gunfights in the Tabarre neighborhood, near the U.S. Embassy,” the alert reads, urging the public to avoid the area.

Tabarre is a municipality located near Port-au-Prince International Airport, northeast of the Haitian capital.

According to a July report by the UN High Commissioner for Human Rights, at least 3,141 people were killed in Haitibetween January 1 and June 30 of this year.

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International

Israel says 136 food aid boxes airdropped into Gaza by six nations

The Israeli military announced on Sunday that 136 boxes of food aid were airdropped into Gaza by the United Arab Emirates, Jordan, Egypt, Germany, and Belgium.

“In recent hours, six countries conducted air drops of 136 aid packages containing food for residents in the southern and northern Gaza Strip,” read the statement, which added that the operation was coordinated by COGAT, the Israeli defense body overseeing civil affairs in the occupied Palestinian territories.

The Israeli military emphasized that they will “continue working to improve the humanitarian response alongside the international community” and reiterated their stance to “refute false allegations of deliberate famine in Gaza.”

The announcement comes as UN agencies warn Gaza faces an imminent risk of famine. More than one in three residents go days without eating, and other nutrition indicators have dropped to their worst levels since the conflict began.

The agencies also noted the difficulty of “collecting reliable data in current conditions, as Gaza’s health systems —already devastated by nearly three years of conflict— are collapsing.”

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Meanwhile, Gaza’s Hamas-run Health Ministry reported on Sunday that hospitals in the enclave recorded six deaths from hunger and malnutrition on Saturday, all of them adults.