International

Gene mutation can slow child growth, puberty: study

AFP

Scientists have identified a gene mutation that affects the brain’s ability to sense a body’s nutrition and can impact childhood growth and delay puberty, a study said Wednesday.

Average human height has increased over time with greater access to food.

By identifying the gene responsible for the brain receptor known as MC3R, scientists may have uncovered one of the reasons behind this trend.

Analysing data from 500,000 participants in the UK Biobank biomedical research database, they identified a few thousand carrying rare natural mutations in the gene responsible for MC3R receptors.

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The study published in Nature shows those individuals were on average shorter and hit puberty later than people without the mutation.

“MC3R deficiency is… associated with reduced childhood growth, adult height and lean mass” the study concludes, noting that the effects are greater the more severe the dysfunction.

Previous studies had shown that mutation in genes responsible for brain receptors known as MC4R lead to obesity in humans.

While studies in mice had suggested MC3R played a role in development, it was not clear how this worked in humans.

“Analysis of the MC3R gene should become part of the routine genetic analysis of patients with delayed puberty, short stature,” the study says.

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It concludes that medically stimulating MC3R receptors might be a potential treatment for delayed puberty, short stature and a condition associated with chronic illness that affects muscle mass known as sarcopenia.

International

Peruvian presidential candidate Napoleón Becerra dies in campaign road accident

Presidential candidate Napoleón Becerra, representing the Partido de los Trabajadores y Emprendedores (PTE) in Peru, died in a traffic accident while traveling to a campaign event, local authorities confirmed Sunday.

Becerra, who also served as president of the centrist political party, ranked among the lowest in opinion polls in a crowded field of more than 30 candidates competing in the presidential election scheduled for April 12.

Recent surveys place Rafael López Aliaga at the top of voter preferences.

The accident occurred near the town of Ayacucho, in southern Peru, when the vehicle carrying the candidate overturned for reasons that remain under investigation.

“The candidate Becerra has died,” Balvin Huamani, mayor of the district of Pilpichaca, told RPP radio.

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According to Huamani, he personally transported the 61-year-old candidate to a local health center, where doctors confirmed his death.

The Jurado Nacional de Elecciones (JNE) expressed condolences over Becerra’s passing and wished a speedy recovery to the three people who were traveling with him and were injured in the crash.

International

Noboa intensifies anti-cartel crackdown as violence persists in Ecuador

A close ally of Washington, Ecuadorian President Daniel Noboa has pursued a hardline security strategy against cocaine cartels for more than two years, yet homicide, disappearance and extortion rates remain high across the country.

Between Sunday night and the morning of March 31, Ecuador’s armed forces will launch a “very strong offensive” with “advisory support” from the United States, Interior Minister John Reimberg announced Tuesday.

The government has kept details of the operation confidential and has not confirmed whether U.S. troops will be deployed on Ecuadorian soil, as has occurred at times during Noboa’s administration.

As part of the security measures, residents in the coastal provinces of Guayas, Los Ríos, Santo Domingo de los Tsáchilas, and El Oro will be subject to a nightly curfew from 11:00 p.m. to 5:00 a.m. local time for the next two weeks.

“We are in a war,” Reimberg said, urging citizens to remain indoors. “Do not take risks. Stay home and allow the security forces and our allies to do the work that must be done.”

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Although Ecuador does not produce cocaine, it has become a major departure point for drugs heading to the United States. Meanwhile, the violence associated with trafficking has increasingly affected the local population.

Bordering the world’s largest cocaine producers, Colombia and Peru, Ecuador has gone from being considered a relatively peaceful country to recording one of the highest homicide rates in Latin America—52 killings per 100,000 inhabitants—according to the **Observatory of Organized Crime.

International

Peruvian presidential candidate proposes death penalty amid crime surge

Peru is facing an unprecedented surge in crime ahead of its presidential election scheduled for April 12, with violence fueled by extortion networks and a wave of contract killings linked to organized crime.

Police data show that 2,200 homicides tied to organized crime were recorded in 2025, while extortion complaints increased by 19%, underscoring the growing security crisis in the South American nation.

Amid this backdrop, presidential candidate Álvarez has proposed reinstating the death penalty if elected, arguing that extreme measures are needed to curb the violence.

To implement the proposal, Álvarez said Peru would withdraw from the American Convention on Human Rights—also known as the Pact of San José—which the country signed in 1978. The agreement prevents member states that have abolished capital punishment from reinstating it.

Currently, Peruvian law only allows the death penalty in cases of treason during wartime.

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“We have to leave the Pact of San José and apply the death penalty in Peru because those miserable criminals don’t deserve to live,” Álvarez told AFP during a campaign stop at a market in Callao, the port city neighboring Lima.

“An iron fist against those criminals,” he added, proposing to declare hitmen as military targets.

During the campaign event, Álvarez walked through stalls selling vegetables, groceries, and fish, greeting vendors while musicians played cumbia music nearby.

The 62-year-old candidate, who spent more than four decades working in television as a comedian, is a newcomer to politics and is running for president under the País para Todos party.

Polls place him fifth in voter preference with nearly 4% support in a fragmented race featuring 36 candidates.