International
FDA approves first twice-yearly HIV prevention shot in the U.S.

The U.S. Food and Drug Administration (FDA) has approved the country’s first twice-yearly injectable HIV prevention treatment, according to an announcement on Wednesday from pharmaceutical company Gilead Sciences.
The medication, named Yeztugo (lenacapavir), is designed to reduce the risk of acquiring HIV through sexual contact in adults and adolescents weighing at least 35 kilograms.
This injectable inhibitor becomes the first and only biannual HIV prevention option available in the United States, offering a longer-lasting alternative for individuals who need or prefer less frequent dosing.
Daniel O’Day, chairman and CEO of Gilead, called the approval a “landmark moment in the decades-long fight against HIV” in an official statement. Clinical trials showed that 99.9% of participants remained HIV-negative after receiving the treatment.
“Yeztugo will help us prevent HIV at a scale never before possible. We now have a way to potentially end the HIV epidemic once and for all,” O’Day said.
Dr. Carlos del Río, co-director of the Emory Center for AIDS Research in Atlanta, noted that the biannual injection could significantly overcome barriers such as adherence and stigma often associated with more frequent dosing regimens.
International
Supreme Court backs Trump move to end TPS for over 300,000 venezuelans

The U.S. Supreme Court on Friday upheld the Trump administration’s decision to revoke Temporary Protected Status (TPS) for more than 300,000 Venezuelan migrants living in the country.
In a 6–3 ruling, the high court sided with the Department of Homeland Security, overturning a previous federal court decision in California that had blocked the suspension of protections for about 600,000 immigrants, including Venezuelans and Haitians. While the ruling paves the way for the potential deportation of hundreds of thousands of Venezuelans, it is not expected to immediately affect Haitian beneficiaries under the program.
“Although the positions in the case have shifted, the legal arguments and the relative harms have not. The same outcome reached in May remains appropriate,” wrote the conservative majority, which had already ruled in a similar direction through emergency measures.
Justices Sonia Sotomayor, Elena Kagan, and Ketanji Brown Jackson dissented. In her opinion, Justice Jackson warned: “I cannot agree with this repetitive, gratuitous, and harmful interference in cases still pending in lower courts while lives hang in the balance.”
President Trump had asked the Supreme Court in late September to authorize the termination of deportation protections that, since 2021, had shielded roughly 300,000 Venezuelans. Lower courts had repeatedly blocked the move.
The ruling marks a temporary conclusion to a legal battle spanning more than two years and grants the administration the green light to move forward with revoking TPS for Venezuelans, despite the possibility of further appeals in lower courts.
International
U.S. government shutdown likely to continue into next week amid Senate deadlock

A U.S. government shutdown is now almost certain to extend into next week, despite another scheduled Senate vote this Friday, as divisions between Democrats and Republicans show no sign of easing.
This will mark the fourth Senate vote since the Republican-led House of Representatives passed a temporary funding bill extending government operations until September 21.
Republicans hold a majority in the Senate with 53 out of 100 seats, but they need at least 60 votes to pass the budget package. Analysts widely expect Friday’s attempt to fall short.
Federal agencies, along with some 750,000 employees, have been left without official funding since Wednesday, when the U.S. fiscal year expired and Congress failed to approve a stopgap measure.
International
Trump plans permanent federal cuts amid partial government shutdown

U.S. President Donald Trump announced on Thursday that he is planning permanent cuts to the federal government as a result of the partial shutdown caused by disagreements between Democrats and Republicans.
The Republican administration also stated that it intends to slash billions of dollars in federal funding to several Democratic-led states. Trump shared on his social media platform Truth Social that he held a meeting with Russell Vought, Director of the Office of Management and Budget, to discuss the planned cuts.
Approximately 750,000 federal employees have been affected since October 1 due to the government shutdown. “I will meet today with Russ Vought to determine which of the many Democratic agencies—most of which are political scams—should be cut, and whether these cuts will be temporary or permanent,” Trump wrote.
“I cannot believe the far-left Democrats have given me this unprecedented opportunity,” he added, referring to the Congressional deadlock.
During the political crisis, Trump has adopted a mocking tone, targeting opponents such as House Minority Leader Hakeem Jeffries and Senate Minority Leader Chuck Schumer. “They are not stupid people, so maybe this is their quiet and swift way of wanting America to be great again,” he added.
The partial government shutdown began Wednesday, following the end of the U.S. fiscal year without a budget extension. Republicans are pushing to continue public spending until November 21.
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