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Cancer drug cooperation could save 1.5 mn lives a year: researchers

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AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

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The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent. 

That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

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‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients. 

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress. 

The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

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“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement. 

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International

Mexico and U.S. Launch New Bilateral Security Group to Combat Fentanyl and Organized Crime

The governments of Mexico and the United States officially launched the Bilateral Implementation Group (BIG) on Friday, a new initiative aimed at strengthening cooperation on security issues and enhancing joint efforts against transnational crime.

In a statement, U.S. Ambassador to Mexico Ronald Johnson announced that he and Deputy Foreign Minister Roberto Velasco addressed officials from both countries who will lead what he described as a “new phase of bilateral cooperation.” The initiative seeks to curb the flow of fentanyl and other illicit drugs, illegal firearms, and human trafficking across the shared border.

Earlier this week, Mexico’s Ministry of Foreign Affairs had confirmed that senior security officials from both nations would meet in Mexico City on June 12 to review and advance existing cooperation agreements.

Through social media, Ambassador Johnson explained that the new bilateral group is designed to improve coordination between the two governments by placing greater emphasis on implementation, accountability, and measurable results. The effort will also focus on combating transnational criminal organizations operating across North America.

“The participation of 15 U.S. government agencies, working alongside their Mexican counterparts, reflects the seriousness of this effort and our shared commitment to delivering measurable results,” Johnson said.

The ambassador also highlighted several achievements that he attributed to ongoing bilateral cooperation. According to Johnson, maritime drug trafficking into the United States has declined by more than 95 percent, while overdose deaths have fallen by 35 percent.

He further noted that Mexican authorities have seized more than 400 metric tons of illegal drugs and dismantled over 2,300 clandestine laboratories as part of their efforts to combat organized crime and narcotics production.

The launch of the Bilateral Implementation Group marks the latest step in the security partnership between Mexico and the United States, as both countries seek to address shared challenges related to drug trafficking, arms smuggling, human trafficking, and the activities of criminal networks operating across the region.

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International

‘El Chapo’ Guzmán again asks Mexican president to seek his return from U.S. prison

Convicted drug trafficker Joaquín “El Chapo” Guzmán has once again appealed to Mexican President Claudia Sheinbaum to intervene on his behalf and seek his transfer from the United States to Mexico, where he hopes to serve the remainder of his prison sentence.

Guzmán, the former leader of the Sinaloa Cartel, is currently serving a sentence of more than 50 years in the United States after being convicted in 2019 on multiple charges, including drug trafficking and money laundering.

According to reports, the latest request was made in a letter dated June 2, one of several messages that Guzmán has reportedly sent to Sheinbaum in recent months in an effort to secure his repatriation. In the letter, he expresses hope that the Mexican government can support the efforts of his legal team.

Written in English and by hand, the letter asks that he be allowed to complete his sentence in Mexico, arguing that such a transfer would enable him to receive visits from family members more easily.

Guzmán is currently being held at the United States Penitentiary Administrative Maximum Facility in Florence, Colorado, commonly known as the “Alcatraz of the Rockies,” one of the most secure prisons in the United States.

As in previous communications, the former cartel leader complained about his prison conditions, stating that he remains in near-total isolation and has little to no contact with other inmates.

He also reiterated his long-standing claim that he did not receive a fair trial in the United States and argued that the Mexican government bears responsibility for much of the violence associated with organized crime in the country.

In the letter, Guzmán maintains that his actions were motivated by a desire to protect himself and his family amid the violence linked to criminal organizations in Mexico.

Mexican authorities have not publicly indicated whether they plan to respond to the request. Guzmán remains one of the most notorious figures in the history of international drug trafficking and is serving his sentence under some of the strictest security measures in the U.S. prison system.

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Central America

U.S. Authorities Accuse Guatemalan Nationals of Using False Information to Sponsor Migrant Minors

Senior officials from the U.S. Department of Justice and the Department of Homeland Security announced Thursday criminal charges against three Guatemalan citizens accused of using false information to sponsor migrant children who crossed the U.S.-Mexico border without a parent or guardian.

According to an indictment filed in Ohio, Maritza Cahuec Coc allegedly submitted at least 12 sponsorship applications, several of which were filed under aliases or contained materially false statements intended to secure custody of the minors.

Under U.S. procedures, unaccompanied migrant children apprehended at the southern border are placed in the custody of the Department of Health and Human Services, which is responsible for their care until they can be released to a qualified sponsor, such as a parent or relative living in the United States.

Prosecutors allege that Cahuec Coc, who reportedly entered the United States illegally in 2018, received payments between late 2020 and 2023 for helping bring 12 migrant minors into the country. Authorities claim she submitted fraudulent documents and misleading information to obtain approval for the sponsorship requests.

The case was announced during a joint press conference led by Acting Deputy Attorney General Todd Blanche and Homeland Security Secretary Markwayne Mullin. However, officials provided limited details about the investigation and instead focused much of their remarks on criticizing immigration policies implemented under the previous administration.

Republican lawmakers and Trump administration officials have frequently pointed to the increase in unaccompanied migrant children arriving at the U.S.-Mexico border during President Joe Biden’s term, arguing that the government failed to adequately oversee their care and placement.

During Thursday’s briefing, A. Tysen Duva, Assistant Attorney General for the Justice Department’s Criminal Division, alleged that Cahuec Coc used the identities of other individuals and falsely claimed family relationships in order to obtain custody of the children.

“Maritza submitted sponsorship applications using other people’s identities and falsely represented that the minors were the children of close relatives in order to secure their release,” Duva said.

The case remains under investigation, and federal authorities have not yet disclosed additional information regarding the other two Guatemalan nationals charged in connection with the alleged scheme.

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