International

Cancer drug cooperation could save 1.5 mn lives a year: researchers

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AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

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The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.

That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

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‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.

The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

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“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.

International

Man arrested after deliberately driving into seven children in Osaka

Japanese police arrested a man on Thursday after he rammed his car into a group of seven schoolchildren in an apparent deliberate attack in the city of Osaka.

The children, who were on their way home from school, sustained injuries and were taken to the hospital. All seven remained conscious, according to local authorities.

An Osaka police officer, speaking on condition of anonymity, said the suspect is a 28-year-old man from Tokyo. The officer shared statements the man made after his arrest: “I was fed up with everything, so I decided to kill people by driving into several elementary school children,” the suspect reportedly said.

The man has been arrested on suspicion of attempted murder.

The injured children, aged between seven and eight, included a seven-year-old girl who suffered a fractured jaw. The six other children—all boys—suffered minor injuries such as bruises and scratches and were undergoing medical evaluation.

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Witnesses described the car as “zigzagging” before hitting the children. One witness told Nippon TV that a girl was “covered in blood” and the others appeared to have scratches.

Another witness said the driver, who was wearing a face mask, looked to be in shock when school staff pulled him from the vehicle.

Violent crimes are rare in Japan, though serious incidents do occur from time to time. In 2008, Tomohiro Kato drove a two-ton truck into pedestrians in Tokyo’s Akihabara district, then fatally stabbed several victims. Seven people were killed in that attack.

Internacionales

Clashes erupt during may day protests across France amid calls for better wages

May Day protests in France were marked by a heavy police presence and clashes between demonstrators and law enforcement in several cities.

In Paris, Lyon, and Nantes, thousands took to the streets to demand better wages, fairer working conditions, and to voice their dissatisfaction with President Emmanuel Macron’s government.

While the majority of the demonstrations remained peaceful, isolated confrontations broke out in some areas. Protesters threw objects at the police, prompting the use of tear gas and resulting in several arrests.

Videos showing police crackdowns circulated widely on social media, drawing criticism from labor unions and human rights advocates, who denounced the authorities’ response to the protests.

International

Kristi Noem credits Trump for mass migrant deportations by mexican president

U.S. Secretary of Homeland Security Kristi Noem claimed that Mexican President Claudia Sheinbaum has deported “more than half a million” migrants due to pressure from former President Donald Trump.

During a cabinet meeting highlighting the “achievements” of Trump’s administration in its first 100 days, Noem asserted that under the Republican leader’s influence, “Mexico has finally come to the table” to negotiate on migration and fentanyl trafficking.

“The president of Mexico told me she has returned just over half a million people before they reached our border,” Noem stated, criticizing media reports that suggest the Biden administration deported more migrants than Trump’s.

“I wish those deportations were counted,” Noem added, “because those people never made it to our border—she sent them back because you made her.” She went on to thank Trump: “They never made it here because they got the message—because you were so aggressive.”

Noem has made controversial claims about Sheinbaum in the past, prompting the Mexican leader to refute them.

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On April 1, Sheinbaum responded to one such statement by declaring, “The president answers to only one authority, and that is the people of Mexico,” after Noem said on Fox News that she gave Sheinbaum “a list of things Trump would like to see” and that Mexico’s actions would determine whether Trump granted tariff relief.