International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
María Corina Machado says Venezuela’s political transition “must take place”
Venezuelan opposition leader María Corina Machado said this Thursday, during a virtual appearance at an event hosted by the Venezuelan-American Association of the U.S. (VAAUS) in New York, that Venezuela’s political transition “must take place” and that the opposition is now “more organized than ever.”
Machado, who is set to receive the Nobel Peace Prize on December 10 in Oslo, Norway — although it is not yet known whether she will attend — stressed that the opposition is currently focused on defining “what comes next” to ensure that the transition is “orderly and effective.”
“We have legitimate leadership and a clear mandate from the people,” she said, adding that the international community supports this position.
Her remarks come amid a hardening of U.S. policy toward the government of Nicolás Maduro, with new economic sanctions and what has been described as the “full closure” of airspace over and around Venezuela — a measure aimed at airlines, pilots, and alleged traffickers — increasing pressure on Caracas and further complicating both air mobility and international commercial operations.
During her speech, Machado highlighted the resilience of the Venezuelan people, who “have suffered, but refuse to surrender,” and said the opposition is facing repression with “dignity and moral strength,” including “exiles and political prisoners who have been separated from their families and have given everything for the democratic cause.”
She also thanked U.S. President Donald Trump for recognizing that Venezuela’s transition is “a priority” and for his role as a “key figure in international pressure against the Maduro regime.”
“Is change coming? Absolutely yes,” Machado said, before concluding that “Venezuela will be free.”
International
Catalonia’s president calls for greater ambition in defending democracy
The President of the Generalitat of Catalonia, Salvador Illa, on Thursday called for being “more ambitious” in defending democracy, which he warned is being threatened “from within” by inequality, extremism, and hate speech driven by what he described as a “politics of intimidation,” on the final day of his visit to Mexico.
“The greatest threat to democracies is born within themselves. It is inequality and the winds of extremism. Both need each other and feed off one another,” Illa said during a speech at the National Autonomous University of Mexico (UNAM) in Mexico City.
In his address, Illa stated that in the face of extremism, society can adopt “two attitudes: hope or fear,” and warned that hate-driven rhetoric seeks to weaken citizens’ resolve. “We must be aware that hate speech, the politics of intimidation, and threats in the form of tariffs, the persecution of migrants, drones flying over Europe, or even war like the invasion of Ukraine, or walls at the border, all pursue the same goal: to make citizens give up and renounce who they want to be,” he added.
Despite these challenges, he urged people “not to lose hope,” emphasizing that there is a “better alternative,” which he summarized as “dialogue, institutional cooperation, peace, and human values.”
“I sincerely believe that we must be more ambitious in our defense of democracy, and that we must remember, demonstrate, and put into practice everything we are capable of doing. Never before has humanity accumulated so much knowledge, so much capacity, and so much power to shape the future,” Illa stressed.
For that reason, he called for a daily defense of the democratic system “at all levels and by each person according to their responsibility,” warning that democracy is currently facing an “existential threat.”
International
WMO predicts 55% chance of weakened La Niña impacting global weather this winter
The World Meteorological Organization (WMO) reported on Thursday that there is a 55% chance that the La Niña phenomenon, typically associated with cooler temperatures, will affect global weather between December and February, though in a weakened form.
In its update released Thursday, the WMO clarified that while La Niña is usually linked to a temporary drop in average global temperatures, some regions could still experience warmer-than-normal conditions.
As 2026 progresses, the WMO expects the planet to shift toward neutral conditions, neither influenced by La Niña nor by its opposite, El Niño, which is associated with increased temperatures. The likelihood of neutral conditions is expected to rise to 75% between February and April, according to the agency’s regular bulletin on these phenomena.
La Niña occurs due to cooling of the central and eastern Pacific Ocean waters and is also linked to changes in tropical atmospheric circulation, including wind and rainfall patterns. The opposite phenomenon, El Niño, has not been observed by experts since 2024, which currently remains the warmest year on record.
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