International
Scientists discover how air pollution triggers lung cancer
AFP | by Daniel Lawler and Isabelle Cortes
Scientists said Saturday they had identified the mechanism through which air pollution triggers lung cancer in non-smokers, a discovery one expert hailed as “an important step for science — and for society”.
The research illustrated the health risk posed by the tiny particles produced by burning fossil fuels, sparking fresh calls for more urgent action to combat climate change.
It could also pave the way for a new field of cancer prevention, according to Charles Swanton of the UK’s Francis Crick Institute.
Swanton presented the research, which has not yet been published in a peer-reviewed journal, at the European Society for Medical Oncology’s annual conference in Paris.
Air pollution has long been thought to be linked to a higher risk of lung cancer in people who have never smoked.
“But we didn’t really know whether pollution was directly causing lung cancer — or how,” Swanton told AFP.
Traditionally it has been thought that exposure to carcinogens, such as those in cigarette smoke or pollution, causes DNA mutations that then become cancer.
But there was an “inconvenient truth” with this model, Swanton said: previous research has shown that the DNA mutations can be present without causing cancer — and that most environmental carcinogens do not cause the mutations.
His study proposes a different model.
A future cancer pill?
The research team from the Francis Crick Institute and University College London analysed the health data of more than 460,000 people in England, South Korea and Taiwan.
They found that exposure to tiny PM2.5 pollution particles — which are less than 2.5 microns across — led to an increased risk of mutations in the EGFR gene.
In laboratory studies on mice, the team showed that the particles caused changes in the EGFR gene as well as in the KRAS gene, both of which have been linked to lung cancer.
Finally, they analysed nearly 250 samples of human lung tissue never exposed to carcinogens from smoking or heavy pollution.
Even though the lungs were healthy, they found DNA mutations in 18 percent of EGFR genes and 33 percent of KRAS genes.
“They’re just sitting there,” Swanton said, adding that the mutations seem to increase with age.
“On their own, they probably are insufficient to drive cancer,” he said.
But when a cell is exposed to pollution it can trigger a “wound-healing response” that causes inflammation, Swanton said.
And if that cell “harbours a mutation, it will then form a cancer”, he added.
“We’ve provided a biological mechanism behind what was previously an enigma,” he said.
In another experiment on mice, the researchers showed that an antibody could block the mediator — called interleukin 1 beta — which sparks the inflammation, stopping cancer from getting started in the first place.
Swanton said he hoped the finding would “provide fruitful grounds for a future of what might be molecular cancer prevention, where we can offer people a pill, perhaps every day, to reduce the risk of cancer”.
Revolutionary
Suzette Delaloge, who heads the cancer prevention programme at France’s Gustave Roussy institute, said the research was “quite revolutionary, because we had practically no prior demonstration of this alternative way of cancer forming.
“The study is quite an important step for science — and for society too, I hope,” she told AFP.
“This opens a huge door, both for knowledge but also for new ways to prevent” cancer from developing, said Delaloge, who was not involved in the research but discussed it at the conference on Saturday.
“This level of demonstration must force authorities to act on an international scale.”
Tony Mok, an oncologist at the Chinese University of Hong Kong, called the research “exciting”.
“It means that we can ask whether, in the future, it will be possible to use lung scans to look for pre-cancerous lesions in the lungs and try to reverse them with medicines such as interleukin 1 beta inhibitors,” he said.
Swanton called air pollution a “hidden killer”, pointing to research estimating it is linked to the deaths of more than eight million people a year — around the same number as tobacco.
Other research has linked PM2.5 to 250,000 deaths annually from lung cancer alone.
“You and I have a choice about whether we smoke or not, but we do not have a choice about the air we breathe,” said Swanton, who is also the chief clinician at Cancer Research UK, which was the main funder of the research.
“Given that probably five times as many people are exposed to unhealthy levels of pollution than tobacco, you can see this is quite a major global problem,” he added.
“We can only tackle it if we recognise the really intimate links between climate health and human health.”
International
Florida officials warn against raw milk after dozens sickened
Unprocessed milk from a farm in Florida has sickened at least 21 people, prompting state authorities to issue a public health alert, U.S. media reported Monday.
The 21 cases include six children under the age of 10, all diagnosed with infections caused by E. coli and Campylobacterbacteria linked to raw milk from the farm in the southeastern U.S. state. Local authorities have also warned about the dangers of drinking unpasteurized milk.
Seven people have been hospitalized, two of whom have suffered complications, according to multiple reports.
The Florida Department of Health has urged the public to avoid raw milk consumption and blamed the outbreak on the farm involved—without naming it directly—citing poor sanitary practices.
Florida law prohibits the sale of unprocessed milk for human consumption, although it can be sold if labeled for pets. Pasteurization, which involves heating milk to kill harmful bacteria, is required under U.S. federal regulations for any dairy products sold across states.
Despite these regulations, sales of raw milk have been increasing in recent years, fueled by online promotion from wellness influencers and advocates of unprocessed foods.
The U.S. Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC) warn that raw milk can contain potentially deadly bacteria such as E. coli, Campylobacter, Listeria, or Salmonella, which can cause symptoms ranging from diarrhea, vomiting, and indigestion to severe complications like kidney failure.
International
Massive wildfire in Southern France kills one, injures nine
Hundreds of firefighters battled on Wednesday to contain a massive wildfire in southern France that has left one person dead and nine others injured.
The blaze, which broke out Tuesday in the Aude department, is the largest recorded in France during the current summer season. Authorities have deployed 1,800 firefighters in an effort to bring it under control.
An elderly woman died in her home in the town of Saint-Laurent-de-la-Cabrerisse, while two others were injured—one in serious condition due to burns—according to the local prefecture. Seven firefighters suffered smoke inhalation injuries, and one person remains missing. The wildfire has already scorched an estimated 12,000 hectares of land.
“The fire is spreading very quickly due to unfavorable weather conditions. This is one of the driest areas of the department, and strong winds are fueling the flames,” said Lucie Roesch, secretary general of the Aude prefecture. Rémi Recio, subprefect for the city of Narbonne, added, “The fire is still spreading and is far from being contained or under control.”
The A9 motorway, which runs along the Mediterranean coast between France and Spain, has been closed in both directions between Narbonne and Perpignan, along with numerous secondary roads.
In Saint-Laurent-de-la-Cabrerisse, the smell of smoke lingers over the charred hectares. A helicopter was seen drawing water from the river below the village and dropping it several kilometers away, AFP reporters observed.
A campsite and at least one village were partially evacuated, with 25 houses and around 35 vehicles damaged, according to a preliminary assessment.
French Prime Minister François Bayrou announced he will visit the affected area on Wednesday.
International
Japan marks 80 years since Hiroshima bombing with call for nuclear disarmament
Japan observed a minute of silence on Wednesday to mark the 80th anniversary of the atomic bombing of Hiroshima, a solemn reminder to the world of the horror it unleashed, amid heightened tensions between nuclear powers the United States and Russia.
At exactly 8:15 a.m. local time (23:15 GMT), the moment when the U.S. bomber Enola Gay dropped the “Little Boy” atomic bomb on August 6, 1945, the city paused to remember.
The bombing claimed an estimated 140,000 lives, not only from the devastating blast and fireball but also from the deadly radiation that followed. Three days later, another bomb dropped on Nagasaki killed 74,000 more. Japan’s surrender on August 15 marked the end of World War II.
On a sweltering morning, hundreds of students, survivors, and officials dressed in black laid flowers at the Hiroshima Peace Memorial. The city’s mayor, Kazumi Matsui, warned of “an accelerating trend toward military buildup worldwide,” citing Russia’s invasion of Ukraine and the ongoing war in the Middle East.
Japanese Prime Minister Shigeru Ishiba stated that Japan has a mission “to take the lead toward a world without nuclear weapons.”
Today, Hiroshima is a thriving metropolis of 1.2 million people, yet the skeletal remains of one building still stand at its center as a powerful reminder of the tragedy.
Wednesday’s ceremony was attended by representatives from around 120 countries and regions, including delegates from Taiwan and Palestine for the first time.
Among the attendees was 96-year-old Yoshie Yokoyama, who arrived in a wheelchair accompanied by her grandson. She told reporters that her parents and grandparents were victims of the bombing.
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