International
Treatment improves cognition in Down Syndrome patients
AFP
A new hormone treatment improved the cognitive function of six men with Down Syndrome by 10-30 percent, scientists said Thursday, adding the “promising” results may raise hopes of improving patients’ quality of life.
However the scientists emphasised the small study did not point towards a cure for the cognitive disorders of people with Down Syndrome and that far more research is needed.
“The experiment is very satisfactory, even if we remain cautious,” said Nelly Pitteloud of Switzerland’s Lausanne University Hospital and co-author of a new study in the journal Science.
Down Syndrome is the most common genetic form of intellectual disability, occurring in around one in 1,000 people, according to the World Health Organization.
Yet previous research has failed to significantly improve cognition when applied to people with the condition, which is why the latest findings are “particularly important”, the study said.
Recent discoveries have suggested that how the gonadotropin-releasing hormone (GnRH) is produced in the brain can affect cognitive functioning such as memory, language and learning.
GnRH hormones regulate how much testosterone and estrogen is produced and increased levels of it help spur puberty.
“We wondered if this hormone could play any role in establishing the symptoms of people with Down Syndrome,” said Vincent Prevot, study co-author and head of neuroscience research at France’s INSERM institute.
– Mice research –
The team first established that five strands of microRNA regulating the production of GnRH were dysfunctional in mice specifically engineered for Down Syndrome research.
They then demonstrated that cognitive deficiencies — as well as loss of smell, a common symptom of Down Syndrome — were linked to dysfunctioning GnRH secretion in the mice.
The team then gave the mice a GnRH medication used to treat low testosterone and delayed puberty in humans, finding that it restored some cognitive function and sense of smell.
A pilot study was conducted in Switzerland involving seven men with Down Syndrome aged 20 to 50.
They each received the treatment through their arm every two hours over a period of six months, with the drug delivered in pulses to mimic the hormone’s frequency in people without Down Syndrome.
Cognition and smell tests were carried out during the treatment, as were MRI scans.
Six of the seven men showed improvement in cognition with no significant side effects — however none showed a change in their sense of smell.
“We have seen an improvement of between 10-30 percent in cognitive functions, in particular with visuospatial function, three-dimensional representation, understanding of instructions as well as attention,” Pitteloud said.
The patients were asked to draw a simple 3D bed at several stages throughout the therapy. Many struggled at the beginning but by the end the efforts were noticeably better.
– ‘Improve quality of life’ –
The authors acknowledged some limitations of the study, including its size and that the choice of patients was “pushed by their parents”.
“The clinical trial only focused on seven male patients — we still have a lot of work to do to prove the effectiveness of GnRH treatment for Down Syndrome,” Pitteloud said.
A larger study involving a placebo and 50 to 60 patients, a third of them women, is expected to begin in the coming months.
“We are not going to cure the cognitive disorders of people with Down Syndrome, but the improvement seen in our results already seems fundamental enough to hope to improve their quality of life,” Pitteloud said.
Fabian Fernandez, an expert in cognition and Down Syndrome at the University of Arizona who was not involved in the research, hailed the “tour de force study”.
He told AFP that while it is “difficult to envision” how such an intensive treatment could be used for young people, it might be better suited to delay the Alzheimer’s disease-related dementia suffered by many adults with Down Syndrome.
It was also difficult to predict how such an improvement could impact the lives of people with the condition, he said.
“For some, it could be significant, however, as it would enable them to be more independent with daily living activities such as maintaining and enjoying hobbies, finding belongings, using appliances in the home, and travelling alone.”
International
Chuck Schumer Unveils Proposal to Strengthen Oversight of the U.S. Presidency
U.S. Senate Democratic Leader Chuck Schumer on Thursday announced legislation to establish a federal anti-corruption office aimed at strengthening oversight of the executive branch and preventing future presidents from using the White House for personal financial gain.
Schumer said the proposal was prompted by what he described as President Donald Trump’s misuse of the presidencyto benefit his family’s business interests.
“In just 18 months, the Trump family has made more than $4 billion by exploiting the influence of the presidency,” Schumer alleged.
The New York senator also argued that the alleged corruption has had direct economic consequences for American households.
“The same corrupt practices Trump is using to pocket billions of dollars are also forcing Americans to pay, on average, $3,100 more each year because of the rising cost of living,” he said.
The legislation was introduced alongside Democratic Senators Alex Padilla, Jeff Merkley, and Andy Kim.
According to Schumer, the bill has two primary objectives: “First, to return money to the American people. Second, to ensure that no one can ever steal from them again.”
He added that the proposal would create legal mechanisms allowing citizens to seek the recovery of funds allegedly obtained through government corruption.
“The fact that Trump stole money from the American people does not make it his. Americans deserve to get that money back,” Schumer said.
Under the proposed legislation, any U.S. citizen—as well as state attorneys general acting on behalf of their residents—would be authorized to file civil lawsuits to recover funds allegedly acquired through corrupt practices by public officials.
“Our bill would empower any individual, including a state attorney general acting on behalf of the people of that state, to bring legal action to recover money stolen from the public through government corruption,” Schumer said.
The measure is expected to face debate in Congress, where Republicans and Democrats remain deeply divided over executive accountability and the scope of presidential powers.
International
Trump Administration Urges Latin America to Increase Defense Spending Against Organized Crime
The administration of U.S. President Donald Trump on Wednesday urged Latin American countries to increase investment in defense and security to strengthen the fight against organized crime and drug trafficking networks.
The appeal was made by Elbridge Colby, the U.S. Under Secretary of Defense for Policy, in an article published by Americas Quarterly. Colby argued that governments across the region should assume greater responsibility for protecting their territories from transnational criminal organizations.
“It is essential that our neighbors in the region invest more in their own defense and security. There is no reason why any country, especially those facing significant narco-terrorist threats, should spend so little on defense,” Colby wrote.
The Pentagon official described it as “absurd” that some Latin American nations allocate less than 1% of their Gross Domestic Product (GDP) to defense, although he did not identify the countries. He contrasted that with NATO members in Europe, many of which are increasing defense expenditures to 3.5% of GDP, with an additional 1.5% devoted to security-related investments.
Colby, who participated earlier this month in the Conference of Defense Ministers of the Americas in Cusco, Peru, said there is “a historic opportunity” for the United States and its regional partners to strengthen cooperation against drug trafficking and other transnational threats.
He also defended the proposed Shield of the Americas, a military partnership promoted by the Trump administration to combat organized crime and supported by several conservative governments in the region. The initiative does not include Brazil or Mexico.
In addition, Colby said the administration’s security strategy includes an updated interpretation of the Monroe Doctrine, the long-standing U.S. foreign policy principle that historically viewed Latin America as part of Washington’s sphere of influence.
“Of course, we recognize that the Monroe Doctrine is controversial in many circles. But it is also frequently misunderstood,” he said.
According to Colby, the United States is not seeking “exploitation, subordination or dependence,” but rather a region characterized by greater prosperity, stability and security.
He also stated that Washington is prepared to use “all available resources,” including the U.S. Armed Forces, to combat drug trafficking and irregular migration. Colby highlighted ongoing counternarcotics operations in the Caribbean, despite criticism from human rights organizations that have questioned some missions over allegations of extrajudicial killings in international waters.
International
FAO and WFP Seek $42 Million to Prepare Southern Africa for Unprecedented El Niño
The Food and Agriculture Organization of the United Nations (FAO) and the World Food Programme (WFP) on Thursday appealed for $42 million to help vulnerable communities in southern Africa prepare for what is expected to be an unprecedented El Niño event.
The funding will enable humanitarian agencies to protect millions of people before worsening weather conditions severely affect agricultural production across the region.
Following a meeting with partners in Maputo, Mozambique, the two UN agencies said they still need to secure $42 million of the $54 million required to assist 2.3 million people in Madagascar, Malawi, Mozambique and Zimbabwe.
In a joint statement, FAO and WFP said the appeal marks the first time the two organizations have launched a large-scale, forward-looking call for anticipatory action, warning that insufficient funding could push the region’s most vulnerable families into a major food security crisis.
“The period before the main planting season is critical for taking action,” said José Luis Fernández, FAO Representative in Mozambique. He stressed that early intervention is both more effective and less costly than responding after crops have failed and productive assets have already been lost.
“With timely and flexible financing, we can help farmers access appropriate seeds and agricultural inputs, protect livestock and water resources, and sustain food production before reduced rainfall causes irreversible damage,” Fernández said.
Claire Conan, WFP Representative in Mozambique, emphasized that acting before disasters strike is more efficient and cost-effective than responding after communities have lost their livelihoods. She added that the agency is working closely with the Mozambican government to translate climate forecasts into preventive measures aimed at reducing the impact of droughts and floods.
The planned interventions include supporting farmers, strengthening food production systems and protecting the food security of the region’s most vulnerable households, with the goal of reducing the risk of widespread hunger.
El Niño is a recurring climate phenomenon characterized by unusually warm sea surface temperatures in the equatorial Pacific Ocean and changes in atmospheric circulation, disrupting weather patterns around the world. Its most recent episode, between 2023 and 2024, was associated with record global temperatures, severe droughts across southern Africa, Central America and northern South America, as well as destructive wildfires, torrential rainfall and widespread flooding.
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