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Treatment improves cognition in Down Syndrome patients

AFP

A new hormone treatment improved the cognitive function of six men with Down Syndrome by 10-30 percent, scientists said Thursday, adding the “promising” results may raise hopes of improving patients’ quality of life.

However the scientists emphasised the small study did not point towards a cure for the cognitive disorders of people with Down Syndrome and that far more research is needed.

“The experiment is very satisfactory, even if we remain cautious,” said Nelly Pitteloud of Switzerland’s Lausanne University Hospital and co-author of a new study in the journal Science.

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Down Syndrome is the most common genetic form of intellectual disability, occurring in around one in 1,000 people, according to the World Health Organization.

Yet previous research has failed to significantly improve cognition when applied to people with the condition, which is why the latest findings are “particularly important”, the study said.

Recent discoveries have suggested that how the gonadotropin-releasing hormone (GnRH) is produced in the brain can affect cognitive functioning such as memory, language and learning.

GnRH hormones regulate how much testosterone and estrogen is produced and increased levels of it help spur puberty.

“We wondered if this hormone could play any role in establishing the symptoms of people with Down Syndrome,” said Vincent Prevot, study co-author and head of neuroscience research at France’s INSERM institute. 

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– Mice research –

The team first established that five strands of microRNA regulating the production of GnRH were dysfunctional in mice specifically engineered for Down Syndrome research.

They then demonstrated that cognitive deficiencies — as well as loss of smell, a common symptom of Down Syndrome — were linked to dysfunctioning GnRH secretion in the mice.

The team then gave the mice a GnRH medication used to treat low testosterone and delayed puberty in humans, finding that it restored some cognitive function and sense of smell.

A pilot study was conducted in Switzerland involving seven men with Down Syndrome aged 20 to 50.

They each received the treatment through  their arm every two hours over a period of six months, with the drug delivered in pulses to mimic the hormone’s frequency in people without Down Syndrome.

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Cognition and smell tests were carried out during the treatment, as were MRI scans.

Six of the seven men showed improvement in cognition with no significant side effects — however none showed a change in their sense of smell.

“We have seen an improvement of between 10-30 percent in cognitive functions, in particular with visuospatial function, three-dimensional representation, understanding of instructions as well as attention,” Pitteloud said.

The patients were asked to draw a simple 3D bed at several stages throughout the therapy. Many struggled at the beginning but by the end the efforts were noticeably better.

– ‘Improve quality of life’ –

The authors acknowledged some limitations of the study, including its size and that the choice of patients was “pushed by their parents”.

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“The clinical trial only focused on seven male patients — we still have a lot of work to do to prove the effectiveness of GnRH treatment for Down Syndrome,” Pitteloud said.

A larger study involving a placebo and 50 to 60 patients, a third of them women, is expected to begin in the coming months.

“We are not going to cure the cognitive disorders of people with Down Syndrome, but the improvement seen in our results already seems fundamental enough to hope to improve their quality of life,” Pitteloud said.

Fabian Fernandez, an expert in cognition and Down Syndrome at the University of Arizona who was not involved in the research, hailed the “tour de force study”.

He told AFP that while it is “difficult to envision” how such an intensive treatment could be used for young people, it might be better suited to delay the Alzheimer’s disease-related dementia suffered by many adults with Down Syndrome.

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It was also difficult to predict how such an improvement could impact the lives of people with the condition, he said.

“For some, it could be significant, however, as it would enable them to be more independent with daily living activities such as maintaining and enjoying hobbies, finding belongings, using appliances in the home, and travelling alone.”

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International

The United States accuses Russia of using chemical weapons against Ukraine

The U.S. State Department determined that Russia has used chemical weapons against Ukraine with agents that constitute a violation of the Chemical Weapons Convention (CAQ) and will impose sanctions on those responsible.

The United States determined that Russia has used chloropicrin, a pesticide used as a suffocating gas in World War I and banned internationally. He has used it in Ukraine to force the departure of troops from fortified positions.

For this reason, the United States has imposed new sanctions on individuals and organizations related to this use of chemical weapons.

“We make this determination, in addition to our conclusion that Russia has used riot control agents as a method of war in Ukraine, also a violation of the CAQ,” the State Department said.

The United States considers that the use of this chemical armament is not isolated and “is probably driven by the desire of the Russian forces to expel Ukrainian forces from fortified positions and achieve tactical advances on the battlefield.”

The Treasury and State Departments sanctioned two people, six Russian entities and four companies. All associated with Russia’s chemical and biological weapons programs.

Chloropicrin is used as a tear agent, but it is prohibited in armed conflicts. In a trench war you can’t escape its effects and you can suffocate.

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International

Trump promises the largest deportation of migrants in history, “they are going to destroy the country”

The former president of the United States and Republican pre-candidate Donald Trump promised to carry out the “highest deportation” of migrants in the country’s history if he returns to the White House after the elections on November 5, because “they are going to destroy the country.”

“Allowing the entry through the southern border of millions and millions of people, many of them very bad, is not sustainable. They are going to destroy the country. We are going to do the biggest deportation in history. We have no other choice,” he said at a campaign rally in Waukesha, in the key state of Wisconsin.

The former president once again accused his rival, Democratic President Joe Biden, of having applied an open border policy during the last four years that has resulted in an “invasion” of migrants.

Trump made these statements a day after an interview with Time magazine was published in which he detailed that he plans to deploy the Army to persecute and detain undocumented migrants if he wins the elections.

In the same interview, he did not rule out the possibility of building new migrant detention camps. Although he did not point it out as a priority since his plan is to deport them quickly.

Trump, who won the elections in 2016 after promising to build a wall on the border with Mexico, has put migration back at the center of his campaign, which has become one of the issues of greatest concern for voters.

The Republican took advantage of a pause in the open criminal trial he has in New York to campaign in Wisconsin and Michigan. Places where he is practically tied with Biden in the polls.

The New York tycoon already visited these two states in the midwest of the country in April and then also insisted on the issue of migration, since he accused the current president of having caused a “bloodbath at the border.”

The Biden Administration annulled Trump’s policy that facilitated the return of hot migrants. It launched humanitarian permit programs for people from several countries, while restricting asylum applications at the border.

More than two million people were arrested last year when crossing the southern border of the United States irregularly.

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International

‘Gaby’ Carrizo, the unpopular ruling presidential candidate for the Presidency of Panama

José Gabriel Carrizo, the current Panamanian vice president, better known as ‘Gaby’, aspires to the historic Democratic Revolutionary Party (PRD) to lead Panama again for another five years after next Sunday’s elections, in which he participates with low popularity rates.

Carrizo, the ruling party’s candidate for the Presidency in conjunction with the Molinera party, and who this Wednesday closes his campaign in Panama City, is at the queue of the polls among the five candidates with options, although the strong base of the PRD in the country, the party of the iconic general Omar Torrijos, cannot be underestimated.

The polls that ‘Gaby’ does lead are those of rejection, with between 50% and 60% of the participants in some surveys who assured that they would “never” vote for him.

“Don’t eat a story (…) we are going to win the elections in a forceful way,” Carrizo said on Wednesday at the closing ceremony of the campaign before a mass of members of the PRD, and assured that the polls “really that they do not want to publish” predict that triumph.

A lawyer by profession, he has been a member of the majority party of Panama since 2007 and in 2019 he became the youngest vice president in Panamanian history at just 36 years old, after Laurentino Cortizo won that year’s elections.

‘Gaby’, 40, has had a lot of visibility within the Executive, which has led to it being popularly pointed out as one of the main faces behind the different scandals that have enveloped the current Government since its inception and that increased with the COVID-19 pandemic.

That year, Carrizo defended the transparent management of the $1,457 million approved during 2020 to combat the pandemic in Panama.

Carrizo has also had a step run over by the presidential debates or during interviews with some media, when making mistakes when explaining his proposals, defending for example that “Panama is safer than France” or that they want to “pass Panama from the first world to the third world.”

This triggered a wave of jokes on social networks that the same candidate used in his favor to campaign with humor, a tone of his political strategy.

In the third and final debate he made the decision not to participate, arguing that José Raúl Mulino, candidate who leads the polls for the Realizing Goals party and substitute for the disabled former President Ricardo Martinelli (2009 – 2014), did not join the debate, as he had not done in the previous ones.

“In the case of the vice president candidate, I think he was looking for an excuse not to come because the last interventions have really been disastrous for him,” José Blandón, the running mate for vice president of Rómulo Roux of Democratic Change, told EFE after the debate.

The youngest of the eight candidates for the Presidency, starts with his main proposal to reduce the working week by maintaining 40 hours in fewer days, a system similar to the one already implemented in some European countries: “Work four days, pound three,” he says on his advertising posters and social networks.

Carrizo has given continuous mass baths in the provinces of Panama during his campaign explaining his electoral promises, which include that cut in working days, salary increases – including for security groups -, free medicines and promotion of tourism, among others.

“When you ask how much 4×8 is (referring to the ruling you had in one of the debates by saying 40 and not 32) answer that there are a thousand sticks (tickets) for your pocket,” the candidate shouts eagerly in one of his videos.

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