International
Treatment improves cognition in Down Syndrome patients
AFP
A new hormone treatment improved the cognitive function of six men with Down Syndrome by 10-30 percent, scientists said Thursday, adding the “promising” results may raise hopes of improving patients’ quality of life.
However the scientists emphasised the small study did not point towards a cure for the cognitive disorders of people with Down Syndrome and that far more research is needed.
“The experiment is very satisfactory, even if we remain cautious,” said Nelly Pitteloud of Switzerland’s Lausanne University Hospital and co-author of a new study in the journal Science.
Down Syndrome is the most common genetic form of intellectual disability, occurring in around one in 1,000 people, according to the World Health Organization.
Yet previous research has failed to significantly improve cognition when applied to people with the condition, which is why the latest findings are “particularly important”, the study said.
Recent discoveries have suggested that how the gonadotropin-releasing hormone (GnRH) is produced in the brain can affect cognitive functioning such as memory, language and learning.
GnRH hormones regulate how much testosterone and estrogen is produced and increased levels of it help spur puberty.
“We wondered if this hormone could play any role in establishing the symptoms of people with Down Syndrome,” said Vincent Prevot, study co-author and head of neuroscience research at France’s INSERM institute.
– Mice research –
The team first established that five strands of microRNA regulating the production of GnRH were dysfunctional in mice specifically engineered for Down Syndrome research.
They then demonstrated that cognitive deficiencies — as well as loss of smell, a common symptom of Down Syndrome — were linked to dysfunctioning GnRH secretion in the mice.
The team then gave the mice a GnRH medication used to treat low testosterone and delayed puberty in humans, finding that it restored some cognitive function and sense of smell.
A pilot study was conducted in Switzerland involving seven men with Down Syndrome aged 20 to 50.
They each received the treatment through their arm every two hours over a period of six months, with the drug delivered in pulses to mimic the hormone’s frequency in people without Down Syndrome.
Cognition and smell tests were carried out during the treatment, as were MRI scans.
Six of the seven men showed improvement in cognition with no significant side effects — however none showed a change in their sense of smell.
“We have seen an improvement of between 10-30 percent in cognitive functions, in particular with visuospatial function, three-dimensional representation, understanding of instructions as well as attention,” Pitteloud said.
The patients were asked to draw a simple 3D bed at several stages throughout the therapy. Many struggled at the beginning but by the end the efforts were noticeably better.
– ‘Improve quality of life’ –
The authors acknowledged some limitations of the study, including its size and that the choice of patients was “pushed by their parents”.
“The clinical trial only focused on seven male patients — we still have a lot of work to do to prove the effectiveness of GnRH treatment for Down Syndrome,” Pitteloud said.
A larger study involving a placebo and 50 to 60 patients, a third of them women, is expected to begin in the coming months.
“We are not going to cure the cognitive disorders of people with Down Syndrome, but the improvement seen in our results already seems fundamental enough to hope to improve their quality of life,” Pitteloud said.
Fabian Fernandez, an expert in cognition and Down Syndrome at the University of Arizona who was not involved in the research, hailed the “tour de force study”.
He told AFP that while it is “difficult to envision” how such an intensive treatment could be used for young people, it might be better suited to delay the Alzheimer’s disease-related dementia suffered by many adults with Down Syndrome.
It was also difficult to predict how such an improvement could impact the lives of people with the condition, he said.
“For some, it could be significant, however, as it would enable them to be more independent with daily living activities such as maintaining and enjoying hobbies, finding belongings, using appliances in the home, and travelling alone.”
International
Florida officials warn against raw milk after dozens sickened
Unprocessed milk from a farm in Florida has sickened at least 21 people, prompting state authorities to issue a public health alert, U.S. media reported Monday.
The 21 cases include six children under the age of 10, all diagnosed with infections caused by E. coli and Campylobacterbacteria linked to raw milk from the farm in the southeastern U.S. state. Local authorities have also warned about the dangers of drinking unpasteurized milk.
Seven people have been hospitalized, two of whom have suffered complications, according to multiple reports.
The Florida Department of Health has urged the public to avoid raw milk consumption and blamed the outbreak on the farm involved—without naming it directly—citing poor sanitary practices.
Florida law prohibits the sale of unprocessed milk for human consumption, although it can be sold if labeled for pets. Pasteurization, which involves heating milk to kill harmful bacteria, is required under U.S. federal regulations for any dairy products sold across states.
Despite these regulations, sales of raw milk have been increasing in recent years, fueled by online promotion from wellness influencers and advocates of unprocessed foods.
The U.S. Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC) warn that raw milk can contain potentially deadly bacteria such as E. coli, Campylobacter, Listeria, or Salmonella, which can cause symptoms ranging from diarrhea, vomiting, and indigestion to severe complications like kidney failure.
International
Massive wildfire in Southern France kills one, injures nine
Hundreds of firefighters battled on Wednesday to contain a massive wildfire in southern France that has left one person dead and nine others injured.
The blaze, which broke out Tuesday in the Aude department, is the largest recorded in France during the current summer season. Authorities have deployed 1,800 firefighters in an effort to bring it under control.
An elderly woman died in her home in the town of Saint-Laurent-de-la-Cabrerisse, while two others were injured—one in serious condition due to burns—according to the local prefecture. Seven firefighters suffered smoke inhalation injuries, and one person remains missing. The wildfire has already scorched an estimated 12,000 hectares of land.
“The fire is spreading very quickly due to unfavorable weather conditions. This is one of the driest areas of the department, and strong winds are fueling the flames,” said Lucie Roesch, secretary general of the Aude prefecture. Rémi Recio, subprefect for the city of Narbonne, added, “The fire is still spreading and is far from being contained or under control.”
The A9 motorway, which runs along the Mediterranean coast between France and Spain, has been closed in both directions between Narbonne and Perpignan, along with numerous secondary roads.
In Saint-Laurent-de-la-Cabrerisse, the smell of smoke lingers over the charred hectares. A helicopter was seen drawing water from the river below the village and dropping it several kilometers away, AFP reporters observed.
A campsite and at least one village were partially evacuated, with 25 houses and around 35 vehicles damaged, according to a preliminary assessment.
French Prime Minister François Bayrou announced he will visit the affected area on Wednesday.
International
Japan marks 80 years since Hiroshima bombing with call for nuclear disarmament
Japan observed a minute of silence on Wednesday to mark the 80th anniversary of the atomic bombing of Hiroshima, a solemn reminder to the world of the horror it unleashed, amid heightened tensions between nuclear powers the United States and Russia.
At exactly 8:15 a.m. local time (23:15 GMT), the moment when the U.S. bomber Enola Gay dropped the “Little Boy” atomic bomb on August 6, 1945, the city paused to remember.
The bombing claimed an estimated 140,000 lives, not only from the devastating blast and fireball but also from the deadly radiation that followed. Three days later, another bomb dropped on Nagasaki killed 74,000 more. Japan’s surrender on August 15 marked the end of World War II.
On a sweltering morning, hundreds of students, survivors, and officials dressed in black laid flowers at the Hiroshima Peace Memorial. The city’s mayor, Kazumi Matsui, warned of “an accelerating trend toward military buildup worldwide,” citing Russia’s invasion of Ukraine and the ongoing war in the Middle East.
Japanese Prime Minister Shigeru Ishiba stated that Japan has a mission “to take the lead toward a world without nuclear weapons.”
Today, Hiroshima is a thriving metropolis of 1.2 million people, yet the skeletal remains of one building still stand at its center as a powerful reminder of the tragedy.
Wednesday’s ceremony was attended by representatives from around 120 countries and regions, including delegates from Taiwan and Palestine for the first time.
Among the attendees was 96-year-old Yoshie Yokoyama, who arrived in a wheelchair accompanied by her grandson. She told reporters that her parents and grandparents were victims of the bombing.
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