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WHO launches call to speed up genomics tech development

AFP

Countries should step up their work on genomic technologies to combat diseases, and share that technology more quickly with developing nations, a new WHO report argued Tuesday.

Genomics — the study of DNA sequences and gene functions — could make a vast contribution to improving human health, said the World Health Organization’s Science Council.

“Genomic technologies are driving some of the most ground-breaking research happening today,” said WHO chief scientist Soumya Swaminathan.

“The benefits of these tools will not be fully realised unless they are deployed worldwide.”

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The report included a series of recommendations designed to help make that happen.

Genomics is the study of the total or part of the genetic sequence information of organisms and attempts to understand the structure and function of those sequences. 

Its supporters hope it will provide efficient, cost-effective and robust means of preventing, diagnosing and treating major diseases.

– ‘Enormous contribution’ –

The Science Council was set up in April last year to advise WHO chief Tedros Adhanom Ghebreyesus on advances in science and technology that could directly improve global health.

Made up of nine leading scientists and public health experts, it is chaired by Professor Harold Varmus, a 1989 Nobel laureate and a former director of the US National Institutes of Health.

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The council chose to focus on genomics because of its successes in confronting infectious diseases, cancers, and other chronic diseases.

Genomics uses biochemistry, genetics, and molecular biology to understand and use biological information in DNA and RNA, with benefits for medicine and public health.

“Genomics can make enormous contributions to human health, from surveying populations for infectious agents, such as the virus that causes Covid-19, to predicting and treating a wide variety of diseases, such as cancers and developmental disorders,” said Varmus.

Genome sequencing data became the basis of global monitoring of both how the SARS-CoV-2 virus was evolving, and the emergence of new Covid variants. It was also used in the development of vaccines.

– Bringing down costs –

It is not ethically or scientifically justifiable for less well-resourced countries to gain access to such technologies long after wealthy nations do, the council’s report argued.

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It advocated expanded access to genomic technologies — particularly outside the richest countries — by addressing shortfalls in financing, laboratory infrastructure, materials, and highly trained personnel.

The costs of establishing and expanding genomic technologies were declining, said the report — but they could be brought down further.

Tiered pricing, shared intellectual property rights and investing profits from one area into another could all help make genomic technologies more affordable, it argued.

Ministries should collaborate with scientific organisations on using genomics, building technical capacity and pooling resources with others, the report added.

But it also said that oversight and adherence to international standards was critical in promoting the ethical and legal use of information obtained with genomic methods.

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International

U.S. Senate Rejects Budget, Bringing Government Closer to Shutdown Amid DHS Dispute

The U.S. Senate voted on Thursday against a budget proposal in a move aimed at pressuring changes at the Department of Homeland Security (DHS), following the killing of two civilians during a deployment of immigration agents in Minneapolis.

All Senate Democrats and seven Republican lawmakers voted against the bill, which requires 60 votes to advance, pushing the country closer to a partial government shutdown that would cut funding for several agencies, including the Pentagon and the Department of Health.

The rejection came as Senate leaders and the White House continue negotiations on a separate funding package for DHS that would allow reforms to the agency. Proposed measures include banning Immigration and Customs Enforcement (ICE) agents from wearing face coverings and requiring them to use body-worn cameras during operations.

The vote took place just hours after President Donald Trump said he was “close” to reaching an agreement with Democrats and did not believe the federal government would face another shutdown, following last year’s record stoppage.

“I don’t think the Democrats want a shutdown either, so we’ll work in a bipartisan way to avoid it. Hopefully, there will be no government shutdown. We’re working on that right now,” Trump said during a Cabinet meeting at the White House.

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Trump Says Putin Agreed to One-Week Halt in Attacks on Ukraine Amid Extreme Cold

U.S. President Donald Trump said on Thursday that he secured a commitment from Russian President Vladimir Putinto halt attacks against Ukraine for one week, citing extreme weather conditions affecting the region.

“Because of the extreme cold (…) I personally asked Putin not to attack Kyiv or other cities and towns for a week. And he agreed. He was very pleasant,” Trump said during a Cabinet meeting broadcast by the White House.

Trump acknowledged that several advisers had questioned the decision to make the call.
“A lot of people told me not to waste the call because they wouldn’t agree. And he accepted. And we’re very happy they did, because they don’t need missiles hitting their towns and cities,” the president said.

According to Trump, Ukrainian authorities reacted with surprise to the announcement but welcomed the possibility of a temporary ceasefire.
“It’s extraordinarily cold, record cold (…) They say they’ve never experienced cold like this,” he added.

Ukrainian President Volodymyr Zelensky later commented on the announcement, expressing hope that the agreement would be honored.

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Storm Kristin Kills Five in Portugal, Leaves Nearly 500,000 Without Power

Storm Kristin, which battered Portugal with heavy rain and strong winds early Wednesday, has left at least five people dead, while nearly half a million residents remained without electricity as of Thursday, according to updated figures from authorities.

The revised death toll was confirmed to AFP by a spokesperson for the National Emergency and Civil Protection Authority (ANPEC). On Wednesday, the agency had reported four fatalities.

Meanwhile, E-Redes, the country’s electricity distribution network operator, said that around 450,000 customers were still without power, particularly in central Portugal.

Emergency services responded to approximately 1,500 incidents between midnight and 8:00 a.m. local time on Wednesday, as the storm caused widespread disruptions.

The Portuguese government described Kristin as an “extreme weather event” that inflicted significant damage across several regions of the country. At the height of the storm, as many as 850,000 households and institutions lost electricity during the early hours of Wednesday.

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Several municipalities ordered the closure of schools, many of which remained shut on Thursday due to ongoing adverse conditions.

Ricardo Costa, regional deputy commander of the Leiria Fire Brigade, said residents continue to seek assistance as rainfall persists.
“Even though the rain is not extremely intense, it is causing extensive damage to homes,” he noted.

In Figueira da Foz, a coastal city in central Portugal, strong winds toppled a giant Ferris wheel, underscoring the severity of the storm.

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