International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
China calls for dialogue amid rising Iran-Israel conflict
The Chinese government emphasized on Monday the importance of “creating the conditions to return to the proper path of dialogue” between Iran and Israel, which have exchanged attacks in recent days resulting in more than 20 Israeli and over 220 Iranian deaths.
Chinese Foreign Ministry spokesperson Guo Jiakun expressed deep concern at a press conference over the Israeli attacks on Iran and the “sudden escalation” of the military conflict.
Guo called on all parties to “take immediate measures to ease tensions and prevent the region from descending into further turmoil,” stating that “force cannot bring lasting peace.”
“If the conflict between Israel and Iran continues to intensify or even expand, the countries of the Middle East will be the first to suffer the consequences,” he added, while noting that China “will continue to maintain communication with the relevant parties, promoting peace and dialogue.”
Chinese Foreign Minister Wang Yi spoke last Saturday with his Iranian and Israeli counterparts to condemn the Israeli airstrike on Iranian territory, which he described as a “violation of international law” with the potential to trigger “disastrous” consequences.
In both calls, Wang reiterated China’s rejection of the use of force, defended diplomacy as the only solution to the Iranian nuclear dispute, and offered China’s mediation to prevent further destabilization in the Middle East.
International
Suspect arrested in killing of Minnesota legislator and husband, governor Says
Minnesota Governor Tim Walz announced on Sunday the arrest of Vance Luther Boelter, 57, the main suspect in the killing of Democratic legislator Melissa Hortman and her husband in a Brooklyn Park suburb on Friday night.
Boelter, who also reportedly shot State Senator John Hoffman and his wife early Saturday morning, was apprehended in Sibley County following an intensive manhunt involving hundreds of law enforcement officers.
In a public statement, Governor Walz condemned Boelter’s “unthinkable actions,” which resulted in the death of a woman who “shaped the core of who we are as a state.”
“We cannot become numb to this. We are a deeply divided nation,” Walz said in a statement posted on his X account.
“We move forward not with hatred or violence, but with humility, grace, and civility,” he added.
Expressing solidarity with the victims’ families, Walz said the entire state of Minnesota is in mourning. He also thanked law enforcement for their bravery and professionalism: “They have saved lives,” he emphasized.
“As we heal, we will not let fear win,” Walz concluded. “We must honor Melissa by moving forward with understanding, service, and above all, humanity.”
Throughout Sunday, police and sheriff units searched a rural area in Minnesota for Vance Luther Boelter, a security company director and preacher who, according to Governor Walz, acted out of politically motivated violence.
International
40,000 tourists stranded in Israel amid airspace shutdown over Iran conflict
Approximately 40,000 tourists are stranded in Israel following the closure of the country’s airspace amid escalating hostilities with Iran, the Israeli Ministry of Tourism reported on Monday.
The ministry has set up a virtual office to provide information via email (virtual@goisrael.gov.il) and phone (+972-53-583-5808), as well as a Facebook page called Israel Virtual Tourist Office.
Israeli Tourism Minister Haim Katz is in contact with hotels and accommodations across the country to offer support to tourists in need, the ministry added.
Many stranded travelers are considering crossing overland into Jordan or Egypt to seek flights from those countries. The Israel Airports Authority reminded the public that land border crossings remain open.
Three German tourists stranded in Jerusalem told EFE today that they have not received any assistance from their country’s embassy in Israel, and their primary option currently is to cross into Jordan to catch a flight from there.
Since early Friday morning, Israel launched operations against Iran, targeting military personnel and infrastructure, including energy and nuclear facilities, as well as numerous residential areas in Tehran.
In response, Iran has fired hundreds of ballistic missiles at Israel, some of which have struck various locations across the country, leaving at least 24 dead so far, according to Israeli authorities.
Iranian health officials report at least 224 deaths, mostly civilians, including at least 17 senior military officials—nine from the Revolutionary Guard—and more than a dozen nuclear scientists.
The Israeli military has warned that many more “targets” remain, while Iran’s Revolutionary Guard declared on Monday that it will continue missile attacks against Israel until its “destruction.”
China calls for dialogue amid rising Iran-Israel conflict
Suspect arrested in killing of Minnesota legislator and husband, governor Says
40,000 tourists stranded in Israel amid airspace shutdown over Iran conflict
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