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Cancer drug cooperation could save 1.5 mn lives a year: researchers

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AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

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More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent. 

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That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients. 

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress. 

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The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement. 

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International

Geert Wilders reaches a provisional agreement to form a government in the Netherlands

The leader of the Dutch extreme right, Geert Wilders, reached a “provisional” agreement on Wednesday to form a government with three other center-right parties, which he will now send to the Dutch Parliament for debate, although they have not yet agreed on behalf of the candidate for prime minister.

As announced by Wilders, leader of the Freedom Party (PVV), there is already a “provisional” agreement with the other three center-right parties: the liberal VVD, the Christian Democrat NSC and the BBB farmers’ party, although there are still disagreements about pensions and “the discussion about who will lead that government will be resumed at a later date” because they have not yet decided on this point.

Wilders won the general elections on November 22, but had to resign his aspiration to the position of prime minister to unblock the dialogue with the other parties.

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International

Diana Boluarte goes to a new interrogation of the Attorney General for the ‘Rolex case’

The president of Peru, Dina Boluarte, arrived this Wednesday unexpectedly at the headquarters of the Public Ministry to be interrogated by the interim Attorney General, Juan Carlos Villena, as part of the preliminary investigation opened for the crimes of corruption and bribery by the so-called ‘Rolex case’.

Boluarte arrived at the tax headquarters, in the historic center of Lima, at 9:20 a.m. (14.20 GMT) sheltered by a large police security display and entered aboard an official van with dark moons.

As has happened on previous occasions, the ruler is not expected to offer subsequent statements about this interrogation.

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International

The filmmaker Rasoulof will go to the Cannes Film Festival after fleeing Iran, according to his lawyer

Iranian filmmaker Mohamad Rasoulof, who fled his country after being sentenced to eight years in prison, will go to the Cannes Film Festival to present his film ‘The seed of the sacred fig’, his lawyer Babak Paknia told EFE.
“He (Rasoulof) will participate in Cannes,” Paknia said on Wednesday.

Rasoulof will present his film ‘The seed of the sacred fig’ at the French festival, which is about a judge who deals with the protests unleashed by the death of the young Iranian Mahsa Amini in 2022 after being arrested for not wearing the Islamic veil well.

Some actors of the film, however, will not be able to attend since the Iranian authorities do not allow them to leave the country, according to Paknia, who also stated that they have opened a new judicial case against the director for the film.

“They have opened a new case for this new film,” said Paknia, who did not explain the charges.

Rasoulof announced two days ago that he had fled his country to Europe after being sentenced to eight years in prison, lashes and the confiscation of property for the crime of “collusion with the intention of committing crimes against the security of the country.”

The filmmaker, winner of the Golden Bear of the Berlinale with ‘The Life of Others’ in 2020, a film that deals with the death penalty in the country, has had numerous problems with the country’s authorities and has been sentenced to prison on three occasions.

He was last arrested in July 2022 for criticizing the repression of protests unleashed by the collapse of a building that caused dozens of deaths two years ago and eight months later he was released.

In recent weeks, Iranian courts have multiplied convictions against artists and academics who are critical of the Islamic Republic.

In one of the most noted cases, a revolutionary court sentenced rapper Tomaj Salehi to death for sedition, propaganda against the system and incitement to riots for supporting the protests unleashed by Amini’s death.

In those protests, young Iranians and women called for the end of the Islamic Republic and only disappeared after a repression that caused 500 deaths and the arrest of at least 22,000 people and in which eight demonstrators were executed, one of them in public.

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