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Scientists discover how air pollution triggers lung cancer

AFP | by Daniel Lawler and Isabelle Cortes

Scientists said Saturday they had identified the mechanism through which air pollution triggers lung cancer in non-smokers, a discovery one expert hailed as “an important step for science — and for society”.

The research illustrated the health risk posed by the tiny particles produced by burning fossil fuels, sparking fresh calls for more urgent action to combat climate change.

It could also pave the way for a new field of cancer prevention, according to Charles Swanton of the UK’s Francis Crick Institute.

Swanton presented the research, which has not yet been published in a peer-reviewed journal, at the European Society for Medical Oncology’s annual conference in Paris.

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Air pollution has long been thought to be linked to a higher risk of lung cancer in people who have never smoked.

“But we didn’t really know whether pollution was directly causing lung cancer — or how,” Swanton told AFP.

Traditionally it has been thought that exposure to carcinogens, such as those in cigarette smoke or pollution, causes DNA mutations that then become cancer.

But there was an “inconvenient truth” with this model, Swanton said: previous research has shown that the DNA mutations can be present without causing cancer — and that most environmental carcinogens do not cause the mutations.

His study proposes a different model.

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A future cancer pill?

The research team from the Francis Crick Institute and University College London analysed the health data of more than 460,000 people in England, South Korea and Taiwan.

They found that exposure to tiny PM2.5 pollution particles — which are less than 2.5 microns across — led to an increased risk of mutations in the EGFR gene.

In laboratory studies on mice, the team showed that the particles caused changes in the EGFR gene as well as in the KRAS gene, both of which have been linked to lung cancer.

Finally, they analysed nearly 250 samples of human lung tissue never exposed to carcinogens from smoking or heavy pollution.

Even though the lungs were healthy, they found DNA mutations in 18 percent of EGFR genes and 33 percent of KRAS genes.

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“They’re just sitting there,” Swanton said, adding that the mutations seem to increase with age.

“On their own, they probably are insufficient to drive cancer,” he said.

But when a cell is exposed to pollution it can trigger a “wound-healing response” that causes inflammation, Swanton said. 

And if that cell “harbours a mutation, it will then form a cancer”, he added.

“We’ve provided a biological mechanism behind what was previously an enigma,” he said.

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In another experiment on mice, the researchers showed that an antibody could block the mediator — called interleukin 1 beta — which sparks the inflammation, stopping cancer from getting started in the first place.

Swanton said he hoped the finding would “provide fruitful grounds for a future of what might be molecular cancer prevention, where we can offer people a pill, perhaps every day, to reduce the risk of cancer”.

Revolutionary

Suzette Delaloge, who heads the cancer prevention programme at France’s Gustave Roussy institute, said the research was “quite revolutionary, because we had practically no prior demonstration of this alternative way of cancer forming.

“The study is quite an important step for science — and for society too, I hope,” she told AFP.

“This opens a huge door, both for knowledge but also for new ways to prevent” cancer from developing, said Delaloge, who was not involved in the research but discussed it at the conference on Saturday.

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“This level of demonstration must force authorities to act on an international scale.”

Tony Mok, an oncologist at the Chinese University of Hong Kong, called the research “exciting”.

“It means that we can ask whether, in the future, it will be possible to use lung scans to look for pre-cancerous lesions in the lungs and try to reverse them with medicines such as interleukin 1 beta inhibitors,” he said.

Swanton called air pollution a “hidden killer”, pointing to research estimating it is linked to the deaths of more than eight million people a year — around the same number as tobacco.

Other research has linked PM2.5 to 250,000 deaths annually from lung cancer alone.

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“You and I have a choice about whether we smoke or not, but we do not have a choice about the air we breathe,” said Swanton, who is also the chief clinician at Cancer Research UK, which was the main funder of the research.

“Given that probably five times as many people are exposed to unhealthy levels of pollution than tobacco, you can see this is quite a major global problem,” he added.

“We can only tackle it if we recognise the really intimate links between climate health and human health.”

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International

Brazil helicopter crash in Rio de Janeiro kills six, including pilots and international figures

The Rio de Janeiro Civil Police confirmed on Monday the identities of three of the six victims killed in a helicopter collision that occurred the previous morning in the Recreio dos Bandeirantes neighborhood.

All three identified victims are Brazilian nationals: the pilots of the aircraft, Charles Marsillac and Alexandre Souza, and music producer Lucas Brito.

The identities of the three foreign victims have not yet been officially confirmed. They include U.S. singer Oliver Tree, Argentine YouTuber Gaspar Prim—known online as “Gaspi”—and Argentine producer Lucas Vignale, all of whom were listed on the flight manifest.

According to police, forensic experts from the Legal Medical Institute have already collected DNA samples in order to identify the foreign victims, whose bodies were severely burned.

One of the helicopters crashed into a private parking lot, triggering a fire that destroyed around twenty electric vehicles. That aircraft was carrying the pilot and four passengers, including the three foreign nationals.

The second helicopter, which had only the pilot on board, crashed approximately 100 meters away from the first impact site.

Rio de Janeiro’s deputy mayor, Eduardo Cavaliere, stated that both helicopters were operating transport flights toward Angra dos Reis on the Rio coastline and toward the mountainous region of the state.

Oliver Tree, 32, was in Brazil as part of an international tour. The artist, known for songs such as “Life Goes On” and “Miss You,” had performed to a large audience in São Paulo a week earlier and was scheduled to continue his tour in Europe.

Argentine content creator Gaspar Prim, 23, had built a following of more than two million on social media platforms, gaining popularity for humorous and often controversial video productions that had occasionally been removed by hosting platforms.

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International

Mexico and U.S. Launch New Bilateral Security Group to Combat Fentanyl and Organized Crime

The governments of Mexico and the United States officially launched the Bilateral Implementation Group (BIG) on Friday, a new initiative aimed at strengthening cooperation on security issues and enhancing joint efforts against transnational crime.

In a statement, U.S. Ambassador to Mexico Ronald Johnson announced that he and Deputy Foreign Minister Roberto Velasco addressed officials from both countries who will lead what he described as a “new phase of bilateral cooperation.” The initiative seeks to curb the flow of fentanyl and other illicit drugs, illegal firearms, and human trafficking across the shared border.

Earlier this week, Mexico’s Ministry of Foreign Affairs had confirmed that senior security officials from both nations would meet in Mexico City on June 12 to review and advance existing cooperation agreements.

Through social media, Ambassador Johnson explained that the new bilateral group is designed to improve coordination between the two governments by placing greater emphasis on implementation, accountability, and measurable results. The effort will also focus on combating transnational criminal organizations operating across North America.

“The participation of 15 U.S. government agencies, working alongside their Mexican counterparts, reflects the seriousness of this effort and our shared commitment to delivering measurable results,” Johnson said.

The ambassador also highlighted several achievements that he attributed to ongoing bilateral cooperation. According to Johnson, maritime drug trafficking into the United States has declined by more than 95 percent, while overdose deaths have fallen by 35 percent.

He further noted that Mexican authorities have seized more than 400 metric tons of illegal drugs and dismantled over 2,300 clandestine laboratories as part of their efforts to combat organized crime and narcotics production.

The launch of the Bilateral Implementation Group marks the latest step in the security partnership between Mexico and the United States, as both countries seek to address shared challenges related to drug trafficking, arms smuggling, human trafficking, and the activities of criminal networks operating across the region.

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International

‘El Chapo’ Guzmán again asks Mexican president to seek his return from U.S. prison

Convicted drug trafficker Joaquín “El Chapo” Guzmán has once again appealed to Mexican President Claudia Sheinbaum to intervene on his behalf and seek his transfer from the United States to Mexico, where he hopes to serve the remainder of his prison sentence.

Guzmán, the former leader of the Sinaloa Cartel, is currently serving a sentence of more than 50 years in the United States after being convicted in 2019 on multiple charges, including drug trafficking and money laundering.

According to reports, the latest request was made in a letter dated June 2, one of several messages that Guzmán has reportedly sent to Sheinbaum in recent months in an effort to secure his repatriation. In the letter, he expresses hope that the Mexican government can support the efforts of his legal team.

Written in English and by hand, the letter asks that he be allowed to complete his sentence in Mexico, arguing that such a transfer would enable him to receive visits from family members more easily.

Guzmán is currently being held at the United States Penitentiary Administrative Maximum Facility in Florence, Colorado, commonly known as the “Alcatraz of the Rockies,” one of the most secure prisons in the United States.

As in previous communications, the former cartel leader complained about his prison conditions, stating that he remains in near-total isolation and has little to no contact with other inmates.

He also reiterated his long-standing claim that he did not receive a fair trial in the United States and argued that the Mexican government bears responsibility for much of the violence associated with organized crime in the country.

In the letter, Guzmán maintains that his actions were motivated by a desire to protect himself and his family amid the violence linked to criminal organizations in Mexico.

Mexican authorities have not publicly indicated whether they plan to respond to the request. Guzmán remains one of the most notorious figures in the history of international drug trafficking and is serving his sentence under some of the strictest security measures in the U.S. prison system.

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