International
Treatment improves cognition in Down Syndrome patients
AFP
A new hormone treatment improved the cognitive function of six men with Down Syndrome by 10-30 percent, scientists said Thursday, adding the “promising” results may raise hopes of improving patients’ quality of life.
However the scientists emphasised the small study did not point towards a cure for the cognitive disorders of people with Down Syndrome and that far more research is needed.
“The experiment is very satisfactory, even if we remain cautious,” said Nelly Pitteloud of Switzerland’s Lausanne University Hospital and co-author of a new study in the journal Science.
Down Syndrome is the most common genetic form of intellectual disability, occurring in around one in 1,000 people, according to the World Health Organization.
Yet previous research has failed to significantly improve cognition when applied to people with the condition, which is why the latest findings are “particularly important”, the study said.
Recent discoveries have suggested that how the gonadotropin-releasing hormone (GnRH) is produced in the brain can affect cognitive functioning such as memory, language and learning.
GnRH hormones regulate how much testosterone and estrogen is produced and increased levels of it help spur puberty.
“We wondered if this hormone could play any role in establishing the symptoms of people with Down Syndrome,” said Vincent Prevot, study co-author and head of neuroscience research at France’s INSERM institute.
– Mice research –
The team first established that five strands of microRNA regulating the production of GnRH were dysfunctional in mice specifically engineered for Down Syndrome research.
They then demonstrated that cognitive deficiencies — as well as loss of smell, a common symptom of Down Syndrome — were linked to dysfunctioning GnRH secretion in the mice.
The team then gave the mice a GnRH medication used to treat low testosterone and delayed puberty in humans, finding that it restored some cognitive function and sense of smell.
A pilot study was conducted in Switzerland involving seven men with Down Syndrome aged 20 to 50.
They each received the treatment through their arm every two hours over a period of six months, with the drug delivered in pulses to mimic the hormone’s frequency in people without Down Syndrome.
Cognition and smell tests were carried out during the treatment, as were MRI scans.
Six of the seven men showed improvement in cognition with no significant side effects — however none showed a change in their sense of smell.
“We have seen an improvement of between 10-30 percent in cognitive functions, in particular with visuospatial function, three-dimensional representation, understanding of instructions as well as attention,” Pitteloud said.
The patients were asked to draw a simple 3D bed at several stages throughout the therapy. Many struggled at the beginning but by the end the efforts were noticeably better.
– ‘Improve quality of life’ –
The authors acknowledged some limitations of the study, including its size and that the choice of patients was “pushed by their parents”.
“The clinical trial only focused on seven male patients — we still have a lot of work to do to prove the effectiveness of GnRH treatment for Down Syndrome,” Pitteloud said.
A larger study involving a placebo and 50 to 60 patients, a third of them women, is expected to begin in the coming months.
“We are not going to cure the cognitive disorders of people with Down Syndrome, but the improvement seen in our results already seems fundamental enough to hope to improve their quality of life,” Pitteloud said.
Fabian Fernandez, an expert in cognition and Down Syndrome at the University of Arizona who was not involved in the research, hailed the “tour de force study”.
He told AFP that while it is “difficult to envision” how such an intensive treatment could be used for young people, it might be better suited to delay the Alzheimer’s disease-related dementia suffered by many adults with Down Syndrome.
It was also difficult to predict how such an improvement could impact the lives of people with the condition, he said.
“For some, it could be significant, however, as it would enable them to be more independent with daily living activities such as maintaining and enjoying hobbies, finding belongings, using appliances in the home, and travelling alone.”
Central America
U.S. and Regional Allies Back Panama Amid Dispute With China
The United States, Bolivia, Costa Rica, Guyana, Paraguay and Trinidad and Tobago issued a joint statement in support of Panama’s sovereignty, arguing that China’s recent actions represent an attempt to politicize maritime trade and undermine the sovereignty of nations in the hemisphere.
“We are closely monitoring China’s selective economic pressure and recent actions affecting vessels flying the Panamanian flag,” the statement released Tuesday said. “Panama is a pillar of our maritime trading system and, as such, must remain free from undue external pressure.”
The statement comes amid growing tensions surrounding the Panama Canal and the operation of key ports linked to global trade.
At the end of January, Panama’s Supreme Court invalidated the legal framework supporting the 1997 concession that granted Panama Ports Company, a subsidiary of CK Hutchison, the right to operate the Balboa and Cristóbal terminals located on the Pacific and Atlantic entrances of the Panama Canal.
The ruling followed mounting pressure from the United States to curb Chinese influence around the strategic waterway, through which roughly 5% of global maritime trade passes.
CK Hutchison, which managed the ports for nearly three decades, rejected the court’s decision and accused Panamanian authorities of illegally confiscating its assets. The company has launched international arbitration proceedings against Panama, seeking more than $2 billion in damages.
Following the court ruling, reports emerged of increased detentions and inspections of Panamanian-flagged vessels in China, actions widely viewed as retaliatory measures.
On Wednesday, China’s Foreign Ministry dismissed the joint statement as “completely unfounded and misleading,” accusing the United States of politicizing port operations and warning that Beijing would take steps to protect its interests in Panama.
International
King Charles III Says U.S.-UK Alliance Is “Irreplaceable and Unbreakable”
King Charles III of the United Kingdom reaffirmed the strength of the British-American relationship on Tuesday during a speech before the United States Congress, describing the alliance between the two nations as “irreplaceable and unbreakable.”
The address, delivered at the Capitol, marked the first speech by a British monarch before Congress since Queen Elizabeth II in 1991 and comes at a time of political tensions between Donald Trump’s administration and the Labour government of Prime Minister Keir Starmer.
“As President Trump himself observed during his state visit to Britain last autumn, the bond of kinship and identity between the United States and the United Kingdom is invaluable and eternal. It is irreplaceable and unbreakable,” the king said.
While reflecting on the upcoming 250th anniversary of U.S. independence, which will be commemorated this year, Charles III stated that the partnership between the two countries “was born out of disagreement, but is no less strong because of it.”
The monarch emphasized the democratic values shared by both nations and noted that major global changes have occurred whenever the two allies found common ground.
“When we have found that way to agree, great changes have taken place not only for the benefit of our peoples, but for all peoples,” he said.
King Charles also quoted British Prime Minister Keir Starmer, who recently described the relationship as “an indispensable alliance.”
Concluding his speech, the monarch described the shared history of the United States and the United Kingdom as “a story of reconciliation, renewal, and an extraordinary partnership.”
He added that Washington and London have forged “one of the most consequential alliances in human history.”
“I pray with all my heart that our alliance continues to defend our shared values, together with our partners in Europe, the Commonwealth, and around the world, and that we ignore calls urging us to become increasingly isolationist,” Charles III stated.
The king ended by urging both nations to “recommit to one another in selfless service to our peoples and to all peoples of the world.”
International
Trump Administration Considers Denying Green Cards Over Political Views
The administration of President Donald Trump is evaluating new immigration guidelines that could deny permanent residency to immigrants based on their political views, according to a report published by The New York Times.
The proposed measures, outlined in internal Department of Homeland Security documents, would instruct immigration officials to take applicants’ public expressions and ideological positions into account when reviewing green card applications.
According to the report, cases involving “possible anti-American and/or antisemitic conduct or ideologies” would need to be referred to higher authorities for additional review.
Even if applicants have not violated any laws, authorities could still reject residency requests if they determine that individuals have “endorsed, promoted, or supported anti-American views.”
Among the factors listed in the guidelines are participation in pro-Palestinian activities, actions considered antisemitic, and the burning of the U.S. flag.
The documents reportedly describe such actions as “heavily negative” factors in immigration evaluations, potentially blocking applicants from obtaining permanent residency and, eventually, U.S. citizenship.
The directives also place particular attention on demonstrations held on university campuses following the 2023 Hamas attacks against Israel.
However, flag burning has previously been recognized by the U.S. Supreme Court as a form of protected free speech under the Constitution.
The proposal has sparked criticism from immigrant advocacy organizations, including the New York Immigration Coalition.
Its president, Murad Awawdeh, warned that the policies could pose a threat to fundamental rights and freedoms.
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