International
Treatment improves cognition in Down Syndrome patients
AFP
A new hormone treatment improved the cognitive function of six men with Down Syndrome by 10-30 percent, scientists said Thursday, adding the “promising” results may raise hopes of improving patients’ quality of life.
However the scientists emphasised the small study did not point towards a cure for the cognitive disorders of people with Down Syndrome and that far more research is needed.
“The experiment is very satisfactory, even if we remain cautious,” said Nelly Pitteloud of Switzerland’s Lausanne University Hospital and co-author of a new study in the journal Science.
Down Syndrome is the most common genetic form of intellectual disability, occurring in around one in 1,000 people, according to the World Health Organization.
Yet previous research has failed to significantly improve cognition when applied to people with the condition, which is why the latest findings are “particularly important”, the study said.
Recent discoveries have suggested that how the gonadotropin-releasing hormone (GnRH) is produced in the brain can affect cognitive functioning such as memory, language and learning.
GnRH hormones regulate how much testosterone and estrogen is produced and increased levels of it help spur puberty.
“We wondered if this hormone could play any role in establishing the symptoms of people with Down Syndrome,” said Vincent Prevot, study co-author and head of neuroscience research at France’s INSERM institute.
– Mice research –
The team first established that five strands of microRNA regulating the production of GnRH were dysfunctional in mice specifically engineered for Down Syndrome research.
They then demonstrated that cognitive deficiencies — as well as loss of smell, a common symptom of Down Syndrome — were linked to dysfunctioning GnRH secretion in the mice.
The team then gave the mice a GnRH medication used to treat low testosterone and delayed puberty in humans, finding that it restored some cognitive function and sense of smell.
A pilot study was conducted in Switzerland involving seven men with Down Syndrome aged 20 to 50.
They each received the treatment through their arm every two hours over a period of six months, with the drug delivered in pulses to mimic the hormone’s frequency in people without Down Syndrome.
Cognition and smell tests were carried out during the treatment, as were MRI scans.
Six of the seven men showed improvement in cognition with no significant side effects — however none showed a change in their sense of smell.
“We have seen an improvement of between 10-30 percent in cognitive functions, in particular with visuospatial function, three-dimensional representation, understanding of instructions as well as attention,” Pitteloud said.
The patients were asked to draw a simple 3D bed at several stages throughout the therapy. Many struggled at the beginning but by the end the efforts were noticeably better.
– ‘Improve quality of life’ –
The authors acknowledged some limitations of the study, including its size and that the choice of patients was “pushed by their parents”.
“The clinical trial only focused on seven male patients — we still have a lot of work to do to prove the effectiveness of GnRH treatment for Down Syndrome,” Pitteloud said.
A larger study involving a placebo and 50 to 60 patients, a third of them women, is expected to begin in the coming months.
“We are not going to cure the cognitive disorders of people with Down Syndrome, but the improvement seen in our results already seems fundamental enough to hope to improve their quality of life,” Pitteloud said.
Fabian Fernandez, an expert in cognition and Down Syndrome at the University of Arizona who was not involved in the research, hailed the “tour de force study”.
He told AFP that while it is “difficult to envision” how such an intensive treatment could be used for young people, it might be better suited to delay the Alzheimer’s disease-related dementia suffered by many adults with Down Syndrome.
It was also difficult to predict how such an improvement could impact the lives of people with the condition, he said.
“For some, it could be significant, however, as it would enable them to be more independent with daily living activities such as maintaining and enjoying hobbies, finding belongings, using appliances in the home, and travelling alone.”
International
Joe Biden finishes prostate cancer radiotherapy at Penn Medicine
Former U.S. President Joe Biden completed his prostate cancer radiotherapy on Monday, a condition he has been managing since 2023.
The 82-year-old touched a ceremonial bell at Penn Medicine in Pennsylvania after his final session, according to a video posted on Instagram by his daughter, Ashley Biden. She expressed gratitude to the doctors and nurses for the care her father received during his treatment.
A spokesperson for Biden told ABC News that it is currently unclear whether the former president will need to continue radiotherapy.
Biden’s prostate cancer was detected during a routine check-up. According to his medical team, it was a localized, slow-growing tumor. At the time of diagnosis, doctors indicated a positive prognosis with no signs of metastasis.
Central America
White House targets Nicaragua over human rights and labor violations
The White House is considering imposing new tariffs of up to 100% on Nicaragua or removing the country from the benefits of the CAFTA-DR free trade agreement, the Office of the United States Trade Representative (USTR) reported Monday.
The USTR determined that Nicaragua’s policies under the Ortega-Murillo regime regarding violations of labor and human rights, as well as the dismantling of the rule of law, are “unreasonable” and constitute a burden on commerce.
The resolution follows an investigation that began on December 10, 2024, when the USTR, based on recommendations from the Section 301 Committee and other advisory bodies, started reviewing the practices of Nicaragua’s government. The process included a public hearing and more than 160 comments and testimonies, including evidence of severe human rights abuses that have been forwarded to the U.S. State Department for evaluation and follow-up.
The report published Monday extensively documents how Nicaragua’s authoritarian practices — including the repression of fundamental freedoms — create a high-risk environment for U.S. businesses and investments.
International
Zelenskyy: Meeting with Trump “Positive” Despite Rejected Missile Request
Ukrainian President Volodymyr Zelenskyy described his reportedly tense meeting with U.S. President Donald Trump last week as “positive,” despite failing to secure Tomahawk missiles for Ukraine. He emphasized what he said was the continued U.S. interest in economic cooperation with Kyiv.
Zelenskyy said Trump backed away from the possibility of sending long-range missiles to Ukraine after a phone call with Russian President Vladimir Putin, held just hours before the U.S. and Ukrainian leaders met on Friday.
“In my view, he doesn’t want an escalation with the Russians until he meets with them,” Zelenskyy told reporters Sunday. His remarks were embargoed until Monday morning.
Ukraine is seeking to purchase 25 Patriot air defense systems from U.S. manufacturers using frozen Russian assets and assistance from partners. However, Zelenskyy noted that acquiring all of them will take time due to long production lines. He said he discussed with Trump potential support to accelerate procurement, possibly through European partners.
According to Zelenskyy, Trump stated during their meeting that Russian President Vladimir Putin’s sweeping demands — that Ukraine cede the entire eastern regions of Donetsk and Luhansk — remain unchanged.
Zelenskyy was diplomatic when describing his encounter with Trump, though reports suggest he faced pressure to accept Putin’s terms — a strategy Trump has reportedly maintained since the tense Oval Office confrontation on February 28, when the Ukrainian leader was publicly scolded for not being “grateful enough” for U.S. aid.
Still, Zelenskyy said that since Trump ultimately supported maintaining the current front line, the overall message was “positive” for Ukraine.
Joe Biden finishes prostate cancer radiotherapy at Penn Medicine
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